Anti-mouse MHC Class II (I-A) (Clone: Y-3P) | Recombinant, in vivo grade

Catalog No.	Product Name	Size	List Price (US$)
PA007553.m2a	In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa	1 mg	150.00
PA007553.m2a	In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa	5 mg	350.00
PA007553.m2a	In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa	25 mg	900.00

Catalog No.

Product Name

Size

List Price (US$)

Quantity

PA007553.m2a

In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa

1 mg

150.00

PA007553.m2a

In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa

5 mg

350.00

PA007553.m2a

In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa

25 mg

900.00

Description

PA007553.m2a: In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa

Recombinant Mouse IgG2a Monoclonal Antibody.
Clone: Y-3P.
Isotype: Mouse IgG2a kappa.
Source: The anti-mouse MHC Class II (I-A) monoclonal antibody (clone: Y-3P) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: Y-3P) specifically binds to mouse MHC Class II (I-A) .
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse MHC Class II (I-A) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The in vivo grade recombinant anti-mouse MHC Class II (I-A) monoclonal antibody of clone Y-3P is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-Mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P)

Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells.

Younes, S. A., et al. PLoS Biol. 2011 Oct;9(10):e1001171. doi: 10.1371/journal.pbio.1001171. PMID: 22022231; PMCID: PMC3191130

One approach to evaluating the importance of antigen stimulation in T-cell dynamics is to determine whether proliferation can be blocked by anti-MHC class II antibodies. ...To that end, we utilized FcγR-/- mice so that the anti-class II antibody would not block T-cell responses by elimination of antigen-presenting cells. ...In such mice, anti-class II antibodies powerfully inhibit antigen-specific in vivo responses. ...Neither anti-IL-15 nor anti-IL-7Rα had any inhibitory effect, but Y3P almost completely inhibited proliferation, indicating that the expansion of cells in this lymphopenic setting required recognition of MHC and presumably of peptide/MHC complexes. ...Here we have shown that the in situ proliferation of MP cells is not inhibited by anti-MHC class II antibody, using a reagent that strikingly inhibits the proliferation of antigen-specific cells in response to antigen challenge and that blocks the rapid proliferation of MP cells transferred to lymphopenic recipients.

(Tags: bioactivity of anti-mouse MHC Class II (I-A) Y-3P; anti-mouse MHC Class II (I-A) Y-3P of low endotoxin)

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Anti-Mouse MHC Class II (I-A) Monoclonal Antibodies

Aalpha, H 2Aa, H2Aa, H2-Aa, Ia 1, Ia1, IAalpha, MHC Class II

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PA007553.m2a: In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P), Mouse IgG2a Kappa

References of Anti-Mouse MHC Class II (I-A) Monoclonal Antibody (Clone: Y-3P)