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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal recombinant human FcRn protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background
The neonatal Fc receptor (FcRn) is responsible for transporting maternal IgGs to fetus/newborns and maintaining the homeostasis of IgGs in adults. FcRn resembles class I major histocompatibility complex in structure, and is composed of a transmembrane heavy chain and an invariant β2 microglobulin. Changes in the affinity of IgGs to FcRn lead to changes in the half-life of engineered IgGs and Fc fusion proteins. Longer half-life of therapeutic antibodies means lower dose and longer interval between administering. For some diagnostic agents, including imaging or radio-labeled agents, a shorter half-life in circulation results in lower non-specific binding and decreased side effects. Therefore, studying the interaction of FcRn and therapeutic antibodies has direct clinical implications.
BP4095: Recombinant human FcRn protein
Source: HEK 293 cell-derived.
Recombinant human FcRn protein is the FcRn (Ala24 - Ser297) and B2M (β2 Microglobulin) fusion protein with Myc tag and His tag at the C-terminus.
Activity: Recombinant human FcRn protein binds to human IgG in a pH dependent manner.
Formulation: 0.2 μM filtered solution of 20 mM Hepes, 150 mM NaCl, pH 7.5.
Endotoxin Level: Less than 1 EU/ug of protein as determined by LAL method.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month from date of receipt, 2 to 8°C as supplied.
3 months from date of receipt, -20°C to -70°C as supplied.
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