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Home > Proteins & Peptides > A-Z Proteins > SARS-CoV-2 (2019-nCoV) Antigen and Antibody Reagents and Discovery Services

SARS-CoV-2 (2019-nCoV) Antigen and Antibody Reagents and Discovery Services

The virus causing Coronavirus Disease 2019 (COVID-19) was named 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and has infected millions of people and caused tens of thousands of death worldwide. Similar to those of other coronaviruses, there are four major structural proteins in SARS-CoV-2, S (spike) protein, E (envelope) protein, M (membrane) protein, and N (nucleocapsid) proteins.
The spike (S) glycoprotein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of virus entry inhibitors, neutralizing antibodies, and vaccines. There are two subunits, S1 and S2, in the SARS-CoV-2 spike glycoprotein. The SARS-CoV and SARS-CoV-2 S proteins mediate viral entry into host cells by binding to a host receptor, angiotensin-converting enzyme 2 (ACE2), through the receptor-binding domain (RBD) in the S1 subunit, and then fusing the viral and host membranes through the S2 subunit. The recombinant ACE2 protein binds to the recombinant spike protein, S1 subunit, and its RBD produced in mammalian cells.
The nucleocapsid (N) phosphoprotein is the most abundant protein in coronavirus. Because the N protein is highly immunogenic and conserved among cornnaviruses, it is often used as a marker in diagnostic immunoassays in the ELISA and colloidal gold-based rapid test kits. However, positive results may be due to past or present infection with non-SARS-CoV-2 coronavirus strains, such as coronavirus HKU1, NL63, OC43, or 229E.
In addition to various SARS-CoV-2 protein and antibody reagents and ELISA kits, Syd Labs provides SARS-CoV-2 spike and nucleocapsid-specific antibody development services from human, rabbit, mouse, and alpaca. We have single B cells, phage display libraries, and even antibody candidates ready for clients' screening to speed up your antibody discovery for therapeutic drug development, diagnostic test kits, and quality control reagent for vaccine development.

SARS-CoV-2 (2019-nCOV or COVID-19 virus) proteins:

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