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Services for synthesis, detection, identification, separation, purification, production, quantification, and modification of oligonucleotides, RNA, DNA, peptides, and proteins, such as peptide synthesis, gene synthesis, DNA cloning and subcloning, protein expression, custom antibody development, cell line generation, cell and tissue culture, and cell-based assays.
    93 Services
  • BS091: SARS-CoV-2 Spike Protein S1 Subunit Rabbit Monoclonal Antibody Development Service

    We immunized rabbits with SARS-CoV-2 S protein S1 subunit, and identified some anti-S1 or RBD-specific rabbit monoclonal antibodies. We measured affinity and pairing possibility of some rabbit monoclonal antibodies, which can be used for clinical diagnostics to detect SARS-CoV-2 antigen. Some rabbit mAbs that we identified have the neutralization function to block the RBD-ACE2 interaction, which is critical for antibody discovery for therapeutics. We have sent some samples of purified antibodies to dianostic and therapeutic companies for confirmation and tests of other applications. Welcome to contact us if you are interested in our rabbit monoclonal antibodies against SARS-CoV-2 Spike protein especially the S1 subunit or RBD (receptor binding domain).

  • BS093: SARS-CoV-2 Nucleocapsid Rabbit Monoclonal Antibody Development Service (N Protein)

    We immunized rabbits with SARS-CoV-2 Nucleocapsid protein, and identified some anti-Nucleocapsid rabbit monoclonal antibodies. We measured affinity and pairing possibility of some rabbit monoclonal antibodies, which can be used for clinical diagnostics to detect SARS-CoV-2 antigen. We have sent some samples of purified antibodies to dianostic companies for confirmation. Welcome to contact us if you are interested in our rabbit monoclonal antibodies against SARS-CoV-2 Nucleocapsid protein.

  • Our complete custom Adeno-associated Virus (AAV) production services include: 1) AAV plasmid vector construction; 2) AAV packaging; 3) AAV purification by iodixanol or column chromatography; 4) AAV titering by qPCR.

    We have always optimized our AAV production systems, including AAV plasmid vector design and construction and low endotoxin plasmid preparation, host cells for AAV packaging, cell culture medium and AAV packaging process, small and large scale AAV purification process.

    Fast turnaround: 2-3 weeks.

  • The most comprehensive murine hybridoma generation for therapeutic antibody services:

    Genetic background: white, black, immunodeficiency, knock-out, and humanized mice; rat; hamster;

    Antigens: proteins, peptides, DNA, cells expressing certain proteins.

    All are done in US.

  • Custom Ilama and alpaca monoclonal antibody development (VHH, sdAb or nanobody) by Ilama or alpaca immunization and phage display screening.

    Production of camel, Ilama or alpaca VHH in E.coli or VHH-Fc in HEK 293 cells.

    Fast turnaround: 4-6 months once the antigen is available.

  • The most comprehensive rabbit polyclonal antibody production services with the gold standard of rabbit immunization service (1 immunization and 4 boosts): custom production of rabbit polyclonal antibodies (pAb) against non-modified, phospho-specific, methylation-specific, and acetylation-specific peptides and proteins; rabbit polyclonal antibodies for ELISA, Western blot, IP, IF, ICC, and IHC applications.

    The highest quality standard in the field of rabbit polyclonal antibody production services: guaranteed ELISA > 1:64,000 (antisera) and > 1: 128,000 (purified antibodies).

    Fast turnaround: 10 weeks once the antigen is available.

  • The most comprehensive rabbit monoclonal antibody production services: custom production of rabbit monoclonal antibodies against non-modified, phospho-specific, methylation-specific, and acetylation-specific peptides and proteins; rabbit monoclonal antibodies for ELISA, Western blot, IP, IF, ICC, and IHC applications. Syd Labs team has successfully developed a large number of high specificity and high affinity rabbit monoclonal antibodies against a wide range of difficult targets such as small molecules, antibody idiotype, and antigens non-immunogenic in murine, camel or Ilama.

    Fast turnaround: 18 weeks once the antigen is available.

  • Single B cell antibody cloning and sequencing has become popular for antibody discovery, especially for those difficult to obtain.  After antigen specific single B cell sorting, the single B cells can be directly used for antibody seqencing or cultured for 2 weeks before antibody sequencing. Single B cell sequencing by Sanger DNA sequencing or next generation sequencing (NGS) has been successfully applied to single B cell antibody technologies.

  • The most comprehensive hybridoma-based mouse monoclonal antibody production services: custom production of monoclonal antibodies against non-modified, phospho-specific, methylation-specific, and acetylation-specific peptides and proteins as well as small molecular compounds; for ELISA, Western blot, IHC, and flow cytometry applications.

    The lowest custom mouse monoclonal antibody production price: $4500.

    Fast turnaround: 24 weeks once the antigen is available.

  • De novo antibody sequencing to obtain the intact amino acid sequence of variable and/or constant regions of monoclonal antibodies by LC-MS/MS.

    Sample requirement: 3-5 mg at 1 mg/ml preferred (minimum: 2 mg at 1 mg/mL).

    Fast turnaround time: 2-3 months per antibody, but may require more time depending on the complexity of analysis.

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