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Services for synthesis, detection, identification, separation, purification, production, quantification, and modification of oligonucleotides, RNA, DNA, peptides, and proteins, such as peptide synthesis, gene synthesis, DNA cloning and subcloning, protein expression, custom antibody development, cell line generation, cell and tissue culture, and cell-based assays.
    93 Services
  • BS093: Anti-SARS-CoV-2 Nucleocapsid Protein (N Protein) Recombinant Rabbit Monoclonal Antibodies

    High sensitivity: the affinity to the SARS-CoV-2 Nucleocapsid protein measured by the Biacore method is as low as 5 pM.

    Antibody pairing: the recombinant rabbit mAbs bind to various epitopes of the SARS-CoV-2 Nucleocapsid protein.

    We have sold recombinant rabbit monoclonal antibodies and licensed some clones to diagnostic companies to develop COVID-19 antigen test kits.

  • BS092: SARS-CoV-2 Specific Human Neutralizing Monoclonal Antibody Development Service

    If clients can provide PBMC from recovered patients or people with vaccines, we do single B cell sorting and culturing. About 70 ul supernatant per well (clonal single B cell) is sent to clients for quick screening. Then we sequence the antibody VH/VL from single B cell clones selected by clients and produce recombinant rabbit single B cell for confirmation.

  • BS091: Anti-SARS-CoV-2 Spike Protein S1 Subunit and RBD Recombinant Rabbit Monoclonal Antibodies (mAbs)

    We immunized rabbits with SARS-CoV-2 S protein S1 subunit, identified a number of anti-Spike S1 and RBD rabbit monoclonal antibodies (mAbs), sequenced and cloned the antibody genes, then expressed and purified the recombinant rabbit Spike S1 protein monoclonal antibodies and Spike RBD mAbs. We measured antigen binding affinity and pairing possibility of some recombinant rabbit mAbs, which can be used for clinical diagnostics to detect the SARS-CoV-2 antigen. Some RBD rabbit mAbs even have the neutralization function to block the RBD-ACE2 interaction, which is critical for antibody discovery for therapeutics.

    High sensitivity: the affinity to the SARS-CoV-2 S1 subunit and RBD domain measured by the Biacore method is as low as 300 pM.

    Antibody pairing: the recombinant rabbit mAbs bind to various epitopes of the SARS-CoV-2 S1 subunit and RBD domain.

  • Custom Ilama and alpaca monoclonal antibody development (VHH, sdAb or nanobody) by Ilama or alpaca immunization and phage display screening.

    Production of camel, Ilama or alpaca VHH in E.coli or VHH-Fc in HEK 293 cells.

    Fast turnaround: 4-6 months once the antigen is available.

  • Our complete custom Adeno-associated Virus (AAV) production services include: 1) AAV plasmid vector construction; 2) AAV packaging; 3) AAV purification by iodixanol or column chromatography; 4) AAV titering by qPCR.

    We have always optimized our AAV production systems, including AAV plasmid vector design and construction and low endotoxin plasmid preparation, host cells for AAV packaging, cell culture medium and AAV packaging process, small and large scale AAV purification process.

    Fast turnaround: 2-3 weeks.

  • The most comprehensive murine hybridoma generation for therapeutic antibody services:

    Genetic background: white, black, immunodeficiency, knock-out, and humanized mice; rat; hamster;

    Antigens: proteins, peptides, DNA, cells expressing certain proteins.

    All are done in US.

  • The most comprehensive rabbit polyclonal antibody production services with the gold standard of rabbit immunization service (1 immunization and 4 boosts): custom production of rabbit polyclonal antibodies (pAb) against non-modified, phospho-specific, methylation-specific, and acetylation-specific peptides and proteins; rabbit polyclonal antibodies for ELISA, Western blot, IP, IF, ICC, and IHC applications.

    The highest quality standard in the field of rabbit polyclonal antibody production services: guaranteed ELISA > 1:64,000 (antisera) and > 1: 128,000 (purified antibodies).

    Fast turnaround: 10 weeks once the antigen is available.

  • The most comprehensive rabbit monoclonal antibody production services: custom production of rabbit monoclonal antibodies against non-modified, phospho-specific, methylation-specific, and acetylation-specific peptides and proteins; rabbit monoclonal antibodies for ELISA, Western blot, IP, IF, ICC, and IHC applications. Syd Labs team has successfully developed a large number of high specificity and high affinity rabbit monoclonal antibodies against a wide range of difficult targets such as small molecules, antibody idiotype, and antigens non-immunogenic in murine, camel or Ilama.

    Fast turnaround: 18 weeks once the antigen is available.

  • Single B cell antibody cloning and sequencing has become popular for antibody discovery, especially for those difficult to obtain.  After antigen specific single B cell sorting, the single B cells can be directly used for antibody seqencing or cultured for 2 weeks before antibody sequencing. Single B cell sequencing by Sanger DNA sequencing or next generation sequencing (NGS) has been successfully applied to single B cell antibody technologies.

  • The most comprehensive hybridoma-based mouse monoclonal antibody production services: custom production of monoclonal antibodies against non-modified, phospho-specific, methylation-specific, and acetylation-specific peptides and proteins as well as small molecular compounds; for ELISA, Western blot, IHC, and flow cytometry applications.

    The lowest custom mouse monoclonal antibody production price: $4500.

    Fast turnaround: 24 weeks once the antigen is available.

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