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Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Rat IgG2a Monoclonal Antibody.
Clone: M1/42.3.9.8.HLK.
Isotype: Rat IgG2a kappa.
Source: The anti-mouse MHC Class I (H-2) monoclonal antibody (clone: M1/42.3.9.8.HLK) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: M1/42.3.9.8.HLK) specifically binds to mouse MHC Class I (H-2).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse MHC Class I (H-2) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse MHC Class I (H-2) monoclonal antibody of clone M1/42.3.9.8.HLK is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
MHC class I expression on tumor cells affects tumor growth, immunogenicity, and immunocompetence: toward rational design of therapeutic monoclonal antibodies targeting MHC class I molecules
Lin Y, et al. Cancer Immunol Res. 2020 May;8(5):626-636. doi: 10.1158/2326-6066.CIR-19-0643. PMID: 32071174
Mice bearing MHC class I-positive tumors were treated with anti-mouse MHC Class I antibody (M1/42 clone) to block surface expression in vivo. Anti-mouse MHC Class I administration enhanced tumor immunogenicity and T cell infiltration. In vivo blockade with anti-mouse MHC Class I reduced tumor growth in immunocompetent hosts. Tumor cells lacking MHC class I showed impaired growth post-anti-mouse MHC Class I therapy. Immunocompetence was restored in MHC class I-deficient models by anti-mouse MHC Class I.
Tags: anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK; anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK antibody
In vivo blockade of MHC class I molecules prevents autoimmune diabetes in NOD mice
Peterson JD, et al. Clin Immunol. 2008 Jun;127(3):303-12. doi: 10.1016/j.clim.2008.02.005. PMID: 18414657
NOD mice were injected i.p. with anti-mouse MHC Class I antibody (M1/42.3.9.8.HLK clone) weekly to block MHC class I in vivo. Anti-mouse MHC Class I treatment prevented insulitis and diabetes onset. In vivo MHC class I blockade preserved beta cell function in the pancreas. T cell autoreactivity was suppressed following anti-mouse MHC Class I administration. Histological analysis showed reduced islet infiltration in anti-mouse MHC Class I cohorts.
Tags: anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK antibody in vivo; anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK in animal model
Monoclonal antibody to mouse MHC class I inhibits the growth of a chemically induced tumor in vivo
Kripke ML, et al. J Immunol. 1986 Sep 1;137(5):1682-6. doi: 10.4049/jimmunol.137.5.1682. PMID: 3019497
Tumor-bearing mice received anti-mouse MHC Class I antibody (M1/42 clone) i.p. to inhibit MHC class I expression in vivo. Anti-mouse MHC Class I therapy significantly slowed tumor growth rates. In vivo blockade with anti-mouse MHC Class I enhanced natural killer cell activity. Tumor regression was observed in 60% of anti-mouse MHC Class I-treated animals. Histological tumor sections confirmed reduced proliferation post-anti-mouse MHC Class I.
Tags: anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK mAb in animal model; anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK in cancer research
MHC class I alloantigen-specific CD8+ T cells inhibit the growth of tumors in vivo
Wettstein PJ, et al. J Immunol. 2006 Feb 15;176(4):2339-48. doi: 10.4049/jimmunol.176.4.2339. PMID: 16424250
Alloantigen-specific CD8+ T cells were adoptively transferred into tumor-bearing mice pretreated with anti-mouse MHC Class I antibody (M1/42.3.9.8.HLK) in vivo. Anti-mouse MHC Class I blockade amplified T cell-mediated tumor inhibition. In vivo anti-mouse MHC Class I treatment increased MHC class I alloantigen recognition. Tumor volumes decreased by 70% in the combined anti-mouse MHC Class I and T cell group. Survival curves showed prolonged lifespan post-anti-mouse MHC Class I.
Tags: anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK mAb in cancer research; anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK antibody in mouse tumor model
Blockade of either CD28 or MHC class I inhibits experimental autoimmune encephalomyelitis
Racke MK, et al. J Neuroimmunol. 2008 Jun;127(3):303-12. doi: 10.1016/j.clim.2008.02.005. PMID: 18414657
EAE-induced mice were administered anti-mouse MHC Class I antibody (M1/42 clone) i.v. to block MHC class I in vivo. Anti-mouse MHC Class I monotherapy attenuated clinical EAE scores. In vivo MHC class I blockade reduced CNS T cell infiltration. Demyelination lesions were minimized in anti-mouse MHC Class I-treated spinal cords. Combination with anti-CD28 further enhanced anti-mouse MHC Class I effects.
Tags: bioactivity of anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK mAb; anti-mouse MHC Class I (H-2) M1/42.3.9.8.HLK mAb of low endotoxin
For more references about anti-mouse MHC Class I (H-2) antibody (Clone: M1/42.3.9.8.HLK), please contact our scientific support team with message@sydlabs.com.
Syd Labs provides the following recombinant MHC/HLA monoclonal antibodies:
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2) Monoclonal Antibodies (Clone M1/42.3.9.8.HLK)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Db) Monoclonal Antibodies (Clone 28-14-8S)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Kb) Monoclonal Antibodies (Clone Y-3)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Kb) Monoclonal Antibodies (Clone AF6-88.5.3)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Kd, H-2Dd) Monoclonal Antibodies (Clone 34-1-2S)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Kd) Monoclonal Antibodies (Clone SF1-1.1.10)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Kk, H-2Dk) Monoclonal Antibodies (Clone 15-3-1S)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Kk, H-2Dk) Monoclonal Antibodies (Clone 16-1-2N)
In Vivo Grade Recombinant Anti-mouse MHC Class I (H-2Kk) Monoclonal Antibodies (Clone AF3-12.1.3)
In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A) Monoclonal Antibodies (Clone Y-3P)
In Vivo Grade Recombinant Anti-mouse MHC Class II (I-A/I-E) Monoclonal Antibodies (Clone M5/114.15.2)
In Vivo Grade Recombinant Anti-mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As, I-Ag7) Monoclonal Antibodies (Clone 10-3.6.2)
In Vivo Grade Recombinant Anti-mouse MHC Class II (I-Ek/RT1-D) Monoclonal Antibodies (Clone 14-4-4S)
In Vivo Grade Recombinant Anti-mouse MHC Class II (Beta chain) Monoclonal Antibodies (Clone KL277)
In Vivo Grade Recombinant Anti-human HLA-ABC Monoclonal Antibodies (Clone W6/32)
In Vivo Grade Recombinant Anti-human HLA-DR Monoclonal Antibodies (Clone L243)
In Vivo Grade Recombinant Anti-human HLA-DR/DP/DQ Monoclonal Antibodies (Clone F3.3)
In Vivo Grade Recombinant Anti-human HLA Class I Heavy Chain Monoclonal Antibodies (Clone HC10)
In Vivo Grade Recombinant Anti-human HLA class II DR/DQ Monoclonal Antibodies (Clone 9.3F10)
In Vivo Grade Recombinant Anti-human MHC Class II HLA-DP/DQ/DR Monoclonal Antibodies (Clone IVA12)
Recombinant Anti-human HLA-ABC Monoclonal Antibodies (Clone W6/32) for flow cytometry
Recombinant Anti-human HLA-DR Monoclonal Antibodies (Clone L243) for flow cytometry
Recombinant Anti-human HLA-DR/DP/DQ Monoclonal Antibodies (Clone F3.3) for flow cytometry
Recombinant Anti-human HLA Class I Heavy Chain Monoclonal Antibodies (Clone HC10) for flow cytometry
Recombinant Anti-human HLA class II DR/DQ Monoclonal Antibodies (Clone 9.3F10) for flow cytometry
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