My Cart   (0)
My Cart [ 0 ]
Home > Antibodies > Anti-Mouse Antibodies (In Vivo) > Anti-Mouse CD3 Monoclonal Antibodies

Anti-Mouse CD3 Monoclonal Antibodies

cluster of differentiation 3, CD3D, CD3E, CD3G

Catalog No. Product Name Size List Price (US$) Quantity
PA007199.r2b In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Rat IgG2b Kappa 1 mg 150.00
PA007199.r2b In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Rat IgG2b Kappa 5 mg 350.00
PA007199.r2b In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Rat IgG2b Kappa 25 mg 900.00
PA007199.m2a In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Mouse IgG2a Kappa 1 mg 150.00
PA007199.m2a In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Mouse IgG2a Kappa 5 mg 350.00
PA007199.m2a In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Mouse IgG2a Kappa 25 mg 900.00
PA007199.m2b In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Mouse IgG2b Kappa 5 mg 400.00
PA007199.m2c In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Mouse IgG2c Kappa 5 mg 400.00
Description

PA007199.m2a: In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Mouse IgG2a Kappa

Recombinant mouse IgG2a Monoclonal Antibody.
Clone: 17A2.
Isotype: Mouse IgG2a Kappa.
Source: The anti-mouse CD3 monoclonal antibody (clone: 17A2) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 17A2) specifically binds to the mouse T cell receptor CD3.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD3 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

PA007199.r2b: In vivo Grade Recombinant Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2), Rat IgG2b Kappa

Recombinant rat IgG2b Monoclonal Antibody.
Clone: 17A2.
Isotype: Rat IgG2b kappa.
Source: The anti-mouse CD3 monoclonal antibody (clone: 17A2) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: 17A2) specifically binds to the mouse T cell receptor CD3.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD3 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-mouse CD3 Monoclonal Antibody (Clone: 17A2)

CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer
Menon AP, et al. Mol Ther Nucleic Acids. 2024 May; 35(2):102198. doi: 10.1016/j.omtn.2024.102198. PMID: 38745854; PMCID: PMC11091522
“The CD3/T cell receptor (TCR) complex is responsible for antigen-specific pathogen recognition by T cells, and initiates the signaling cascade necessary for activation of effector functions. CD3 agonistic antibodies are commonly used to expand T lymphocytes in a wide range of clinical applications, including in adoptive T cell therapy for cancer patients. [...] The aptamers improved efficacy and persistence of adoptive T cell therapy by low-affinity TCR-reactive T lymphocytes in melanoma-bearing mice.”
(Tags: anti-mouse CD3 clone 17A2; CD3 agonistic antibody)
Murine RAW Macrophages Are a Suitable Model to Study the CD3 Signaling in Myeloid Cells
Castro K, et al. Cells. 2022 May 13; 11(10):1635. doi: 10.3390/cells11101635. PMID: 35626672; PMCID: PMC9139304
“In recent years, a growing body of evidence has shown the presence of a subpopulation of macrophages that express CD3, especially in the context of mycobacterial infections. [...] This work aimed to evaluate the expression of CD3 in a murine macrophage cell line and its potential for the study of CD3 signaling. [...] Our study provides evidence to support that RAW cells are a suitable model to study the function and signaling of the CD3 complex in myeloid cells.”
(Tags: CD3 expression in macrophages; anti-mouse CD3 antibody 17A2)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza A, Chang HD, Radbruch A, et al. Eur J Immunol. 2021 Dec; 51(12):2708-3145. doi: 10.1002/eji.202170126. PMID: 34910301; PMCID: PMC11115438
“The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical diagnostics and specific subsets of immune cells.”
(Tags: flow cytometry murine cells; anti-mouse CD3 clone 17A2 flow cytometry)
Rigid crosslinking of the CD3 complex leads to superior T cell stimulation
Nelson AD, Wang L, et al. Front Immunol. 2024; 15:1406456. PMID: 39281668; PMCID: PMC11392757
“Functionally bivalent non-covalent Fab dimers (Bi-Fabs) specific for the TCR/CD3 complex promote CD3 signaling on T cells. While comparing functional responses to stimulation with Bi-Fab, F(ab')2 or mAb specific for the same CD3 epitope, we observed fratricide requiring anti-CD3 clustering. [...] Thus, increasing rigidity of Fab-CD3 crosslinking between opposing effector-target pairs may result in stronger T cell effector function.”
(Tags: T cell stimulation CD3; anti-mouse CD3 17A2 mAb)
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival
Shirali AS, et al. J Clin Invest. 2018 Nov 1; 128(11):4943-4956. doi: 10.1172/JCI120923. PMID: 30277476; PMCID: PMC6205374
“The targeted delivery of therapeutic drugs to lymph nodes (LNs) provides an unprecedented opportunity to improve the outcomes of transplantation and immune-mediated diseases. [...] Here, we have synthesized a nanoparticle (NP) as a carrier of anti-CD3, and optimized the conjugation strategy to coat the NP surface with MECA79 mAb (MECA79-anti-CD3-NP) to enhance LN accumulation. [...] Short-term treatment of murine cardiac allograft recipients with MECA79-anti-CD3-NP resulted in significantly prolonged allograft survival in comparison with the control groups.”
(Tags: MECA79-anti-CD3-NP; anti-mouse CD3 17A2 in vivo)

For more references about Anti-mouse CD3 Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.

Syd Labs provides the following in vivo grade recombinant anti-human CD3 monoclonal antibodies:
Muromonab biosimilar, research grade, anti-human CD3 monoclonal antibody (Clone: OKT3)
Teplizumab biosimilar, research grade, anti-human CD3 monoclonal antibody (Clone: OKT3)
Foralumab biosimilar, research grade, anti-human CD3 monoclonal antibody (Clone: OKT3)
Recombinant Anti-human CD3 monoclonal antibody (Clone: OKT3)
Recombinant Anti-human CD3 monoclonal antibody (Clone: SP34-2)
Recombinant Anti-human CD3 monoclonal antibody (Clone: UCHT1)
Recombinant Anti-human CD3 monoclonal antibody (Clone: 12F6)

Syd Labs provides the following in vivo grade recombinant anti-human CD3 bispecific antibodies:
Recombinant Anti-human CD3 / CD3 Bispecific Antibody (Clone: OKT3 / UCHT1)
Recombinant Anti-human CD3 / CD3 Bispecific Antibody (Clone: OKT3 / SP34-2)
Recombinant Anti-human CD3 / CD3 Bispecific Antibody (Clone: SP34-2 / OKT3)

Syd Labs provides the following in vivo grade recombinant anti-mouse CD3 monoclonal antibodies:
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: 145-2C11)
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: 500A2)
Recombinant Anti-mouse CD3 monoclonal antibody (Clone: 17A2)
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: KT3)

Syd Labs provides the following recombinant anti-human CD3 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD3 monoclonal antibody (Clone: OKT3) for flow cytometry
Recombinant Anti-human CD3 monoclonal antibody (Clone: UCHT1) for flow cytometry
Recombinant Anti-human CD3 monoclonal antibody (Clone: 12F6) for flow cytometry
Recombinant Anti-human CD3 monoclonal antibody (Clone: SP34-2) for flow cytometry

Syd Labs provides the following recombinant anti-mouse CD3 monoclonal antibodies for flow cytometry:
Recombinant Anti-mouse CD3 monoclonal antibody (Clone: 17A2) for flow cytometry
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: 145-2C11) for flow cytometry
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: 500A2) for flow cytometry
Recombinant Anti-mouse CD3e monoclonal antibody (Clone: KT3) for flow cytometry

Related Links
Anti Mouse CD3 17A2 Antibody, Rat IgG2b kappa
Anti-Mouse CD3 Monoclonal Antibodies for Flow Cytometry(Clone: 17A2)
Anti-mouse CD3e Monoclonal Antibody (Clone: 500A2)
Anti-mouse CD3e Monoclonal Antibody (Clone: KT3)
Anti-Mouse CD3e Monoclonal Antibodies for Flow Cytometry(Clone: 145-2C11)
Super savings and terrific tips sent to your email inbox:

See our Privacy Policy

Best Sales of Products
D-Luciferin Potassium Salt
dNTP Mix, 10 mM each
dNTP mix, 25 mM each
Taq DNA Polymerases
2x High Yield PCR Master Mix
Reverse Transcriptases
2x Hot-start High-fidelity PCR Master Mix
Hot Start Taq DNA Polymerase
Hot-Start High-Fidelity DNA Polymerase
Anti-DNP Monoclonal Antibodies
Biotinylated Human PD-L1 Protein
Best Sales of Services
Rabbit Polyclonal Antibody Production Services
Mouse Monoclonal Antibody Production Services
Antibody Sequencing, Hybridoma Sequencing
Recombinant Antibody (IgG) Production Services
Recombinant Antibody (scFv) Production Services
Antibody Humanization Service
Generation of Stable Cell Lines Expressing Antibodies
Fc Fusion Protein Production Services
DNA Subcloning Services
Real-time PCR (qPCR) Service
Company
Contact Us
About Us
Our Distributors
Careers
Privacy Policy
Terms & Conditions
Sitemap
A  B  C  D  E  F  G  H  I
J  K  L  M  N  O  P  Q  R
S  T  U  V  W  X  Y  Z  0-9

Copyright © 2009-2026 sydlabs.com. All rights reserved.

Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.

Friend Link: Ushelf