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Human IgG4 Fc Protein

Human Fc Protein (IgG4), Human IgG4 Fc region

Catalog No. Product Name Size List Price (US$) Quantity
BP4093 In Vivo Grade Recombinant Human IgG4 Fc Protein 1 mg 350.00


Human Fc (IgG4) is the tail region of an immunoglobulin G4 (IgG4) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG4’s hinge is shorter than that of IgG1, its flexibility is intermediate between IgG1 and IgG2 and some rotation may occur around the glycine residue in its hinge region.

BP4093: In Vivo Grade Recombinant Human IgG4 Fc protein

The recombinant human IgG4 Fc protein was produced in HEK 293 cells and purified by protein A.
Purity: >95% by SDS-PAGE under reducing conditions
Endotoxin Level: Less than 1 EU/ug of protein as determined by LAL method.
Formulation: 0.2 µM filtered solution of 100 mM HEPES, 0.2% sodium acetate, pH 6.

Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month from date of receipt, 2 to 8°C as supplied.
3 months from date of receipt, -20°C to -70°C as supplied.

Other Recombinant IgG Fc Proteins:
Recombinant Human Fc Protein (IgG1)
Recombinant Human Fc Protein (IgG2)
Recombinant Mouse Fc Protein (IgG1)

Recombinant IgG Reference Antibodies:
Recombinant Human IgG1 Reference Antibody
Recombinant Human IgG2 Reference Antibody
Recombinant Human IgG4-S228P Reference Antibody
Recombinant Mouse IgG1 Reference Antibody
Recombinant Mouse IgG2a Reference Antibody
Recombinant Mouse IgG2b Reference Antibody

Fc ELISA Kits and Reagents:
Human Fc ELISA Kit
Mouse Fc ELISA Kit
Human Fc ELISA Reagent Kit
Mouse Fc ELISA Reagent Kit

Protein A, Resin, Columns, and ELISA Kits:
Recombinant Protein A
Protein A Affinity Resin
Pre-packed Protein A Column
Protein A ELISA Kit

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