C007P: Abatacept Biosimilar
Recombinant protein composed of the extracellular domain of CTLA-4 fused with the Fc region of human immunoglobulin gamma 1 (hIgG1).
Specificity/Sensitivity: The abatacept biosimilar protein specifically binds to the human CTLA-4.
Applications: Functional assays, and those assays for studying biological pathways affected by abatacept.PA007578.m2a: In Vivo Grade Recombinant Anti-mouse CD80 (B7-1) Monoclonal Antibody (Clone: 16-10A1), Mouse IgG2a Kappa
Recombinant mouse IgG2a Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 16-10A1) specifically binds to mouse CD80 (B7-1).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD80 (B7-1) protein.PA007578.hs2: In Vivo Grade Recombinant Anti-mouse CD80 (B7-1) Monoclonal Antibody (Clone: 16-10A1), Armenian Hamster IgG2
Recombinant Hamster IgG2 Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade recombinant hamster monoclonal antibody (clone: 16-10A1) specifically binds to mouse CD80 (B7-1).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD80 (B7-1) protein.PA007579.r2a: In Vivo Grade Recombinant Anti-mouse CD80 (B7-1) Monoclonal Antibody (Clone: 1G10), Rat IgG2a Kappa
Recombinant Rat IgG2a Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: 1G10) specifically binds to mouse CD80 (B7-1).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD80 (B7-1) protein.C008P: Belatacept Biosimilar
Recombinant protein composed of the extracellular domain of CTLA-4 fused with the Fc region of human immunoglobulin gamma 1 (hIgG1).
Specificity/Sensitivity: The belatacept biosimilar protein specifically binds to the human CTLA-4.
Applications: Functional assays, and those assays for studying biological pathways affected by belatacept.BP005208: Biotinylated Human B7-1/CD80 Protein with the C-His-Avi Tag
Source: The recombinant Biotinylated Human B7-1/CD80 Protein, (amino acids Val35-Asn242) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Biotinylated Human B7-1 protein with the C-His-Avi tag at 0.5 ug/ml (100 ul/Well) on streptavidin (5 ug/ml) precoated plate. Dose response curve for the recombinant Human CTLA-4 protein with the C-hFc tag with the EC50 of 1.8 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP003999: Biotinylated Human CD8 alpha/CD8A Protein with the C-His-Avi Tag
Source: The recombinant Biotinylated Human CD8 alpha/CD8A Protein, (amino acids Ser22-Asp182) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Anti-CD8 Antibody protein with the C-His-Avi tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Human CD8 alpha protein with the C-His tag with the EC50 of 4.8 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.PA005160-ANT-133: CD80 Monoclonal Antibody
Rat Monoclonal Antibody;
Applications: FACS, IHC, WB;
Reactivity: Mouse;
Clone: mB7-1;
Isotype: Rat IgG2a.BP005182: Cynomolgus B7-1/CD80 Protein with the C-His Tag
Source: The recombinant Cynomolgus B7-1/CD80 Protein, (amino acids Val35-Asn242) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human CTLA-4 protein with the C-His tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Cynomolgus B7-1 protein with the C-His tag with the EC50 of 0.23 ug/ml determined by ELISA (QC Test). The affinity constant of 9.90 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP003722: Cynomolgus CD83 Protein with the C-His Tag
Source: The recombinant Cynomolgus CD83 Protein, (amino acids Thr20-Glu147) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Cynomolgus CD83 protein with the C-His tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Anti- CD83 Antibody protein with the C-hFc tag with the EC50 of 5.7 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.C025P: Durvalumab Biosimilar, PD-L1 Monoclonal Antibody
Recombinant Humanized IgG1 Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade durvalumab biosimilar specifically binds to the human programmed cell death ligand 1 (PD-L1), blocking its interaction with PD-1 and B7-1.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by durvalumab.