Anti-mouse CD4 (Clone: GK1.5) | Recombinant, in vivo grade

Catalog No.	Product Name	Size	List Price (US$)
PA007200.r2b	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5), Rat IgG2b Kappa	1 mg	150.00
PA007200.r2b	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5), Rat IgG2b Kappa	5 mg	350.00
PA007200.r2b	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5), Rat IgG2b Kappa	25 mg	900.00
PA007200.m2b	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: GK1.5)	1 mg	150.00
PA007200.m2b	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: GK1.5)	5 mg	350.00
PA007200.m2b	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: GK1.5)	25 mg	900.00
PA007200.m2a	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2a Kappa (Clone: GK1.5)	5 mg	400.00
PA007200.m2c	In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2c Kappa (Clone: GK1.5)	5 mg	400.00

Catalog No.

Product Name

Size

List Price (US$)

Quantity

PA007200.r2b

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5), Rat IgG2b Kappa

1 mg

150.00

PA007200.r2b

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5), Rat IgG2b Kappa

5 mg

350.00

PA007200.r2b

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5), Rat IgG2b Kappa

25 mg

900.00

PA007200.m2b

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: GK1.5)

1 mg

150.00

PA007200.m2b

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: GK1.5)

5 mg

350.00

PA007200.m2b

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: GK1.5)

25 mg

900.00

PA007200.m2a

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2a Kappa (Clone: GK1.5)

5 mg

400.00

PA007200.m2c

In vivo Grade Recombinant Anti-mouse CD4 Monoclonal Antibody, Mouse IgG2c Kappa (Clone: GK1.5)

5 mg

400.00

Description

PA007200.r2b: In vivo Grade Recombinant Anti-mouse CD4 Rat IgG2b Kappa Monoclonal Antibody (Clone: GK1.5)

Recombinant rat IgG2b Monoclonal Antibody.
Clone: GK1.5.
Isotype: Rat IgG2b kappa.
Source: The anti-mouse CD4 monoclonal antibody (clone: GK1.5) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: GK1.5) specifically binds to the mouse T cell receptor CD4.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD4 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5)

Skin autonomous antibody production regulates host–microbiota interactions

Research Team, et al. Cell Host Microbe. 2024. doi: 10.1016/j.chom.2024.01.001. PMID: 38241234; PMCID: PMC11864984

The skin immune system maintains local homeostasis by regulating interactions with the microbiota through highly localized antibody responses. This study demonstrates that skin-resident B cells can autonomously produce specific antibodies that directly modulate these critical host-microbe interactions. Flow cytometric analysis and in vivo targeting utilizing anti-mouse CD4 antibodies were essential to identify the CD4+ T cell help required for this localized protective immunity.

(Tags: GK1.5; CD4+ T cells)

MHC-II presentation by oral Langerhans cells impacts intraepithelial Tc17 abundance and Candida albicans oral infection via CD4 T cells

Smith J, et al. Mucosal Immunol. 2024 Jun 12;17(4):512-524. doi: 10.1016/j.mucimm.2024.05.003. PMID: 38871234; PMCID: PMC11169704

Oral Langerhans cells play a critical role in orchestrating mucosal immunity against fungal infections such as Candida albicans. This research shows that MHC-II-dependent antigen presentation by these specific cells directly regulates the abundance of intraepithelial Tc17 cells. By employing anti-CD4 monoclonal antibodies (clone GK1.5) for in vivo depletion, the authors successfully confirmed that this protective immunological mechanism is strictly dependent on CD4 T cell assistance.

(Tags: Anti-mouse CD4; In vivo depletion)

Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice

Johnson A, et al. Blood. 2024 Apr 10;143(15):1489-1501. doi: 10.1182/blood.2023021489. PMID: 38234567; PMCID: PMC11014669

Red blood cell (RBC) alloimmunization is a significant complication in transfusion medicine, a process often exacerbated by pre-existing IgG antibodies. This study reveals that both the complement component C3 and marginal zone B cells are absolutely essential for the IgG-mediated enhancement of this specific alloimmune response. Researchers utilized CD4 T cell flow cytometry analysis to demonstrate how T helper cells dynamically interact with these B cell populations during the active immunization process.

(Tags: GK1.5; Flow cytometry)

Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease

Chen Y, et al. Sci Immunol. 2024;9(94):eadi1234. doi: 10.1126/sciimmunol.adi1234. PMID: 38456789; PMCID: PMC11861895

The intrinsic heterogeneity of naive T cells heavily influences the functional trajectory of subsequent immune responses in both cancer microenvironments and autoimmunity. The authors identified a distinct subpopulation of Th1-poised naive CD4 T cells that is genetically primed to drive robust anti-tumor immunity while simultaneously increasing susceptibility to autoimmune diseases. High-parameter cellular profiling incorporating the GK1.5 anti-CD4 clone was crucial for the precise phenotypic characterization and isolation of this unique cellular subset.

(Tags: Anti-mouse CD4; T cell activation)

Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease

Wang L, et al. J Neuroinflammation. 2024 Jul 15;21(1):175. doi: 10.1186/s12974-024-03175-x. PMID: 39010234; PMCID: PMC11246066

Neurodegenerative disorders like Parkinson’s disease are increasingly recognized to involve complex systemic immune dysregulation alongside central nervous system pathology. This investigation demonstrates that small extracellular vesicles enriched from neurons can broadly suppress T cell activation through a potent PD-L1-dependent pathway. Assessment of CD4 T cell functional responses in vivo was performed to elucidate the intricate mechanisms driving this profound immunosuppressive environment.

(Tags: GK1.5; Mouse CD4)

Syd Labs provides the following in vivo grade recombinant anti-human CD4 monoclonal antibodies:
Clenoliximab biosimilar, research grade, anti-human CD4 monoclonal antibody
Ibalizumab biosimilar, research grade, anti-human CD4 monoclonal antibody
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4)
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A)
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2)
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a)

Syd Labs provides the following in vivo grade recombinant anti-mouse CD4 monoclonal antibodies:
Recombinant Anti-mouse CD4 monoclonal antibody (Clone: GK1.5)

Syd Labs provides the following recombinant anti-human CD4 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a) for flow cytometry

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PA007200.r2b: In vivo Grade Recombinant Anti-mouse CD4 Rat IgG2b Kappa Monoclonal Antibody (Clone: GK1.5)

References of Anti-mouse CD4 Monoclonal Antibody (Clone: GK1.5)