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Home > Antibodies > Anti-Human Antibodies (In Vivo) > Anti-Human CD4 Monoclonal Antibodies

Anti-Human CD4 Monoclonal Antibodies

cluster of differentiation 4, leu-3, T4

Catalog No. Product Name Size List Price (US$) Quantity
PA007384.m2b In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: OKT4), Mouse IgG2b Kappa 1 mg 150.00
PA007384.m2b In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: OKT4), Mouse IgG2b Kappa 5 mg 350.00
PA007384.m2b In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: OKT4), Mouse IgG2b Kappa 25 mg 900.00
Description

PA007384.m2b: In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: OKT4)

Recombinant mouse IgG2b Monoclonal Antibody. 
Clone: OKT4.
Isotype: Mouse IgG2b kappa.
Source: The anti-human CD4 monoclonal antibody (clone: OKT4) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: OKT4) specifically binds to human CD4.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD4 protein. 
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions.

Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Background

The recombinant OKT4 antibody binds to the human CD4 protein (cluster of differentiation 4), a glycoprotein and the co-receptor for the T-cell receptor (TCR). The CD4 protein is expressed on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells.

References of anti-human CD4 antibody (OKT4):


Administration of prednisolone in vivo affects the ratio of OKT4/OKT8 and the LDH-isoenzyme pattern of human T lymphocytes
Tenbergen, F., et al. (1984). Clin Immunol Immunopathol. 1984 Feb;30(2):191-202. doi: 10.1016/0090-1229(84)90010-2. PMID: 6607798
The OKT4 antibody (anti-human CD4) was used to assess T lymphocyte subsets in healthy volunteers treated with prednisolone (10, 30, or 60 mg). Prednisolone induced T lymphocytopenia, preferentially affecting OKT4+ cells, leading to a decreased OKT4/OKT8 ratio and altered lactate dehydrogenase isoenzyme patterns, with effects varying by dose and time post-administration.
Tags: anti-human CD4 OKT4; anti-human CD4 OKT4 antibody

In vivo activated cytotoxic T cells in the thyroid infiltrate of patients with Hashimoto's thyroiditis
Del Prete, G. F., et al. (1986). Clin Exp Immunol. 1986 Jul;65(1):140-7. PMID: 3024884
The OKT4 antibody (anti-human CD4) was used with complement for negative selection to enrich T8+ cells in thyroid-infiltrating lymphocytes from Hashimoto’s thyroiditis patients. High T8+ cell proportions with an inverted T4/T8 ratio were observed, and OKT4 helped confirm low CD4+ cell presence in TAC+ T cell populations.
Tags: anti-human CD4 OKT4 antibody in vivo; anti-human CD4 OKT4 in animal model

Human CD4 modulation in vivo induced by antibody treatment
Horneff, G., et al. (1993). Clin Immunol Immunopathol. 1993 Jan;66(1):80-90. doi: 10.1006/clin.1993.1011. PMID: 8440076
The OKT4 antibody (anti-human CD4) was used to monitor CD4 modulation in vivo after anti-CD4 antibody (MAX.16H5) treatment. CD4 antigen density was reduced to 30% within 1 hour and remained down-modulated for up to 28 days, with depletion of CD4+ cells observed in both responders and non-responders to therapy.
Tags: anti-human CD4 OKT4 mAb in animal model; anti-human CD4 OKT4 in cancer research

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
Jin, X., et al. (1999). J Exp Med. 1999 Mar 15;189(6):991-1000. doi: 10.1084/jem.189.6.991. PMID: 10075982
The OKT8F antibody (anti-human CD8) was used to deplete CD8+ cells in SIV-infected macaques, resulting in a 99.9% reduction in peripheral blood CD8 cells and a 70-fold increase in plasma viremia. The OKT4 antibody (anti-human CD4) was used to assess the resting CD4+ T cell pool, revealing increased productively infected cells.
Tags: anti-human CD4 OKT4 mAb in cancer research; anti-human CD4 OKT4 antibody in human tumor model

Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody
Rijlaarsdam, J. U., et al. (1982). Eur J Immunol. 1982 Nov;12(11):979-82. doi: 10.1002/eji.1830121116. PMID: 6759145
The OKT4 antibody (anti-human CD4) was used to confirm stable CD4 expression on T cells during OKT3 treatment, which rapidly modulated the OKT3 epitope within 30 minutes via internalization. OKT4 and OKT8 epitopes remained unaffected, with OKT4 aiding in monitoring T-cell populations during transient lymphocytopenia.
Tags: bioactivity of anti-human CD4 OKT4 mAb; anti-human CD4 OKT4 mAb of low endotoxin

For more references about anti-human CD4 antibody (OKT4), please contact our scientific support team with message@sydlabs.com.

Syd Labs provides the following in vivo grade recombinant anti-human CD4 monoclonal antibodies:
Clenoliximab biosimilar, research grade, anti-human CD4 monoclonal antibody
Ibalizumab biosimilar, research grade, anti-human CD4 monoclonal antibody
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4)
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A)
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2)
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a)

Syd Labs provides the following in vivo grade recombinant anti-mouse CD4 monoclonal antibodies:
Recombinant Anti-mouse CD4 monoclonal antibody (Clone: GK1.5)

Syd Labs provides the following recombinant anti-human CD4 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a) for flow cytometry

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