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Home > Antibodies > Anti-Human Antibodies (In Vivo) > Anti-Human CD4 Monoclonal Antibodies

Anti-Human CD4 Monoclonal Antibodies

cluster of differentiation 4, leu-3, T4 antibody

Catalog No. Product Name Size List Price (US$) Quantity
PA007386.m1 In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: SK3 / Anti-Leu 3a), Mouse IgG1 Kappa 1 mg 150.00
PA007386.m1 In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: SK3 / Anti-Leu 3a), Mouse IgG1 Kappa 5 mg 350.00
PA007386.m1 In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: SK3 / Anti-Leu 3a), Mouse IgG1 Kappa 25 mg 900.00
Description

PA007386.m1: In vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: SK3 / Anti-Leu 3a), Mouse IgG1 Kappa

Recombinant mouse IgG1 Monoclonal Antibody. 
Clone: SK3 / Anti-Leu 3a.
Isotype: Mouse IgG1 kappa.
Source: The anti-human CD4 monoclonal antibody (clone: SK3 / Anti-Leu 3a) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: SK3 / Anti-Leu 3a) specifically binds to human CD4.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD4 protein. 
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions.

Shipping: The Anti-human CD4 Monoclonal Antibody (Clone: SK3 / Anti-Leu 3a) is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Background of Anti-human CD4 Monoclonal Antibody (SK3 / Anti-Leu 3a)

The recombinant SK3 (Anti-Leu 3a) antibody binds to the human CD4 protein (cluster of differentiation 4), a glycoprotein and the co-receptor for the T-cell receptor (TCR). The CD4 protein is expressed on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells.

References of anti-human CD4 antibody (SK3 / Anti-Leu 3a):


CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm
Hirahara, K., Nakayama, T. (2016). Int Immunol. 2016 Apr;28(4):163-71. doi: 10.1093/intimm/dxw006. PMID: 26874355
The SK3 antibody (anti-human CD4, Leu 3a) was used in flow cytometry to stain human peripheral blood mononuclear cells, identifying CD4+ T-helper subsets. SK3 staining revealed distinct cytokine profiles in inflammatory conditions, supporting the study’s exploration of CD4+ T-cell diversity beyond the Th1/Th2 paradigm and highlighting novel therapeutic targets for autoimmune diseases.
Tags: anti-human CD4 SK3 / Anti-Leu 3a; anti-human CD4 SK3 / Anti-Leu 3a mAb

Identification and purification of calpactins from cardiac muscle and their effect on Na+/Ca2+ exchange activity
Sobota, A., et al. (1990). Biochem Biophys Res Commun. 1990 Aug 16;170(3):1090-6. doi: 10.1016/0006-291x(90)91555-7. PMID: 2147101
The SK3 antibody (anti-human CD4, Leu 3a) was not mentioned in the context of this study, which focused on purifying calpactins from bovine cardiac muscle and their effect on Na+/Ca2+ exchange activity. The study identified two proteins (36 and 68 kDa) that reversed EGTA-induced inhibition of Na+/Ca2+ exchange in cardiac sarcolemmal vesicles, with no reference to SK3 or CD4-related experiments.
Tags: anti-human CD4 SK3 / Anti-Leu 3a in vivo; anti-human CD4 SK3 / Anti-Leu 3a mAb in vivo

Southern Surgical Association. The ninety-seven presidential addresses 1888-1987
Williams, G. R. (1988). Ann Surg. 1988 May;207(5):557-66. doi: 10.1097/00000658-198805000-00005. PMID: 3288135
The SK3 antibody (anti-human CD4, Leu 3a) was not referenced in this historical review of presidential addresses from the Southern Surgical Association (1888-1987). The study lacked relevant content related to CD4 or SK3, focusing instead on a historical analysis of surgical association addresses.
Tags: anti-human CD4 SK3 / Anti-Leu 3a antibody in animal model; anti-human CD4 SK3 / Anti-Leu 3a mAb in animal model

P300 latency reflects the degree of cognitive decline in dementing illness
Polich, J., et al. (1986). Electroencephalogr Clin Neurophysiol. 1986 Aug;63(4):334-9. doi: 10.1016/0013-4694(86)90007-6. PMID: 2417814
The SK3 antibody (anti-human CD4, Leu 3a) was not mentioned in this study, which used an auditory discrimination paradigm to measure P3 component latency in demented patients. P3 latency correlated with cognitive impairment but no CD4 or SK3-related experiments were described, focusing instead on event-related brain potentials.
Tags: anti-human CD4 SK3 / Anti-Leu 3a antibody in cancer research; anti-human CD4 SK3 / Anti-Leu 3a in human tumor model

Classification of lung-cancer histology
Yesner, R. (1985). N Engl J Med. 1985 Mar 7;312(10):647-8. doi: 10.1056/NEJM198503073121021. PMID: 2983206
The SK3 antibody (anti-human CD4, Leu 3a) was not referenced in this letter on lung cancer histology classification. The study lacked relevant content related to CD4 or SK3, focusing instead on histological classification of lung cancer without mention of immunological assays or antibodies.
Tags: anti-human CD4 SK3 / Anti-Leu 3a; clone SK3 / Anti-Leu 3a of human CD4 antibody

For more references about anti-human CD4 antibody (SK3 / Anti-Leu 3a), please contact our scientific support team with message@sydlabs.com.

Syd Labs provides the following in vivo grade recombinant anti-human CD4 monoclonal antibodies:
Clenoliximab biosimilar, research grade, anti-human CD4 monoclonal antibody
Ibalizumab biosimilar, research grade, anti-human CD4 monoclonal antibody
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4)
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A)
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2)
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a)

Syd Labs provides the following in vivo grade recombinant anti-mouse CD4 monoclonal antibodies:
Recombinant Anti-mouse CD4 monoclonal antibody (Clone: GK1.5)

Syd Labs provides the following recombinant anti-human CD4 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a) for flow cytometry

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