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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant rat IgG2b isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant rat IgG2b Monoclonal Antibody.
Clone: YTS191.
Isotype: Rat IgG2b kappa.
Source: The anti-mouse CD4 monoclonal antibody (clone: YTS191) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: YTS191) specifically binds to mouse CD4.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD4 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse CD4 monoclonal antibody of clone YTS191 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells
Burrack, K. S., et al. PLoS Pathog. 2015 Oct 5;11(10):e1005191. doi: 10.1371/journal.ppat.1005191. PMID: 26436766
Arg1 activity has also been associated with higher viral loads and lower CD4+ T cell counts from HIV-seropositive patients [33,42] and with inhibition of CD8+ T cell responses in hepatitis B virus (HBV) and hepatitis C virus (HCV)-infected patients. ...To investigate this hypothesis, WT and LysMcre;Arg1F/F mice were treated with anti-CD4 and anti-CD8? antibodies, or an isotype control antibody, on days 7 and 12 pi to deplete CD4+ and CD8+ T cells. ...After gating on lymphocytes, CD8+ T cells were identified by staining positive for CD3 and CD8; CD4+ T cells were identified by gating on CD3+CD8- cells followed by gating on CD3+CD4+ cells. ...The three activation markers that we evaluated are known to be upregulated on antigen-experienced T cells: CD44, CD11a, and CD69. ...Both CD4+ and CD8+ T cell subsets isolated from LysMcre;Arg1F/F mice expressed increased levels of IFN-? compared to T cells sorted from WT mice.
Tags: anti-mouse CD4 YTS191; anti-mouse CD4 YTS191 mAb
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
Fahey, L. M., et al. J Exp Med. 2011 May 9;208(5):987-99. doi: 10.1084/jem.20101773. PMID: 21536743
We now demonstrate that CD4 T cell function is not extinguished as a result of viral persistence. ...Depending on the level of TCR stimulation and the composition of co-stimulatory and inflammatory signals, CD4 T cells differentiate into a variety of helper subsets that in turn orchestrate diverse immune responses. ...CD4 T cells continue to help CD8 T cells during persistent viral infection, allowing continued control over virus replication. ...Given that ongoing antiviral immune responses continually exert control over virus replication throughout persistent infection and that CD4 T cells play an integral role in this process, we sought to define how viral persistence impacts CD4 T cell differentiation such that it is capable of maintaining antiviral immunity in the face of prolonged periods of viral replication. ...Thus, we demonstrate that CD4 T cells are not without function during viral persistence, but instead that their developmental program is redirected from promoting memory T and B cell differentiation after acute viral infection and toward a T helper subset that sustains multiple immune parameters to fight persistent viral infection.
Tags: anti-mouse CD4 YTS191 antibody in vivo; anti-mouse CD4 YTS191 in animal model
For more references about Anti-mouse CD4 Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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