Custom Ilama and alpaca monoclonal antibody development (VHH, sdAb or nanobody) by Ilama or alpaca immunization and phage display screening.
Production of camel, Ilama or alpaca VHH in E.coli or VHH-Fc in HEK 293 cells.
Fast turnaround: 4-6 months once the antigen is available.Syd Labs provides not only stable cell line generation services for protein and antibody production but also cell culture services for small to large scales of previously developed stable cell lines expressing proteins or antibodies. If needed, Syd Labs also provide the process development service for cell culture of stable cell lines and the protein and antibody purification services.
BP4114: Recombinant endotoxin-free TEV protease
Source: E.coli-derived.
Purity: >95% by SDS-PAGE under reducing conditions.
Activity: Recombinant endotoxin-free TEV protease cleaves after Gln in the recognition sequence Glu-Asn-Leu-Tyr-Phe-Gln.
Endotoxin Level: Less than 1 EU/ug of protein as determined by LAL method.Syd Labs determines the titer of lentiviruses and retroviruses (provided by customer or produced by Syd Labs) using HT1080 cells.
Fast return: 2 weeks.
Our FcRγ binding assay and FcRn binding assay services include: his-tagged receptors are immobilized onto anti-His biosensors; the loaded biosensors are dipped into a dilution series of the antibody; the on- (Kon) and off-rates (Koff) are measured and the KD value is calculated.
Our epitope binning service include: Antigen is immobilized onto a biolayer interferometry (BLI) sensor using an appropriate method. Antibody 1 is allowed to saturate its epitope on the antigen. Binding of Antibody 2 to antigen saturated with Antibody 1 is assessed.
Fast turnaround: 2-3 weeks.
APIM050141: DEFACTINIB (VS-6063, PF-04554878)
CAS No.: 1073154-85-4.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.APIM050205: NILOTINIB
CAS No.: 641571-10-0.
Purity: >99% (HPLC).
QC: HPLC, 1HNMR, and Elemental Analysis Report.
Solubility: Soluble in DMSO.APIM050240: SERABELISIB (MLN1117, INK1117, TAK-117)
CAS No.: 1268454-23-4.
Purity: 99.5% by HPLC.
QC: HPLC-MS. 1H-NMR, and Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.APIM050287: S63845 (S-63845)
CAS No.: 1799633-27-4.
Purity: 99.9-100% by Achiral and Chiral HPLCs.
QC: Achiral and Chiral HPLCs, 1H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.