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Background Information:
A tyrosine kinase inhibitor (TKI) specifically targeting Bcr-Abl— the definitive causative abnormality in CML—and its mutant forms, and is significantly more selective and potent inhibitor of Bcr-Abl than imatinib.
Reference:
1. Harmon B, Campbell N, Ratner L. Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step. PLoS Pathog. 2010 Jun 17;6(6):e1000956. PubMed PMID: 20585556.
2. Haubeiss S, Schmid JO, Muerdter TE, Sonnenberg M, Friedel G, van der Kuip H, Aulitzky WE. Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts. Mol Cancer. 2010 Jun 27;9(1):168.
3. Koren-Michowitz M, le Coutre P, Duyster J, Scheid C, Panayiotidis P, Prejzner W, Rowe JM, Schwarz M, Goldschmidt N, Nagler A. Activity and tolerability of nilotinib: a retrospective multicenter analysis of chronic myeloid leukemia patients who are imatinib resistant or intolerant. Cancer. 2010 Jun 22. [Epub ahead of print] PubMed PMID: 20572041.
APIM050205: NILOTINIB
CAS No.: 641571-10-0.
Molecular Formula: C28H22F3N7O.
Molecular Weight: 529.5.
Purity: >99% (HPLC).
QC: HPLC, 1HNMR, and Elemental Analysis Report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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