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Recombinant anti-mouse CD8a monoclonal antibodies from the variable region sequences of the rat anti-mouse CD8a monoclonal antibody (clone number: YTS 169.4) are produced from mammalian cells and good for in vitro and in vivo studies.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
The rat anti-mouse CD8a monoclonal antibody clone YTS 169.4 specifically reacts with the mouse CD8a protein—a T-cell surface glycoprotein encoded by the CD8A gene. As a critical component of the dimeric CD8 protein, CD8a is essential for cell-mediated immune defense and T-cell development. Beyond its physiological role, CD8A is recognized as a vital diagnostic and prognostic marker in inflammatory disorders and various tumor models.
Our in vivo grade recombinant anti-mouse CD8a monoclonal antibody (clone YTS 169.4) is engineered to provide superior performance over traditional hybridoma-derived products. By utilizing a low endotoxin production platform, we ensure that each batch meets stringent requirements for in vivo CD8+ T cell depletion assays. Our recombinant YTS 169.4 antibodies possess the complete amino acid sequences of the original hybridoma clone, guaranteeing high-fidelity binding, exceptional batch-to-batch consistency, and the reliability required for pristine, publication-ready research datasets.
The in vivo grade recombinant anti-mouse CD8a mouse IgG2a monoclonal antibody was produced in mammalian cells.
Specificity: CD8a.
Clone: YTS 169.4.
Isotype: mouse IgG2a, kappa.
Applications: Western blot, immunohistochemistry (IHC), Flow Cytometry (FC), and in vivo CD8+ T cell depletion.
Formulation: 0.2 μM filtered solution of 1x PBS.
Purity: >95% by SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.
The in vivo grade recombinant anti-mouse CD8a rat IgG2b monoclonal antibody was produced in mammalian cells.
Specificity: CD8a.
Clone: YTS 169.4.
Isotype: rat IgG2b, kappa.
Applications: Western blot, immunohistochemistry (IHC), Flow Cytometry (FC), and in vivo CD8+ T cell depletion.
Formulation: 0.2 μM filtered solution of 1x PBS.
Purity: >95% by SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.
Shipping: The in vivo grade recombinant anti-mouse CD8a antibodies (clone of YTS 169.4) are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month from date of receipt, 2 to 8°C as supplied.
12 months from date of receipt, -20°C to -70°C as supplied.
Yes, clone YTS 169.4 is highly effective for in vivo CD8+ T cell depletion in mouse models. Syd Labs provides a recombinant, sequence-defined, low-endotoxin version of clone YTS 169.4, engineered to ensure exceptional depletion efficiency with minimal non-specific immune activation.
While both clone YTS 169.4 and clone 2.43 target the mouse CD8α chain and can be utilized for in vivo CD8+ T cell depletion, they are derived from completely distinct hybridoma lineages. Researchers often select the YTS 169.4 clone to fulfill specific multi-color flow cytometry staining designs or when literature dictates this particular clone to avoid secondary cross-reactivity in specific animal protocols.
Syd Labs' recombinant YTS 169.4 antibody features the precise variable regions of the original rat hybridoma, expressed with a high-purity rat IgG2b kappa constant region (or its recombinant switch variants). It is formulated in 1x PBS, completely azide-free, and processed through our specialized low endotoxin platform to guarantee safety and efficacy in functional assays.
Traditional hybridoma lines suffer from genetic drift and inherent batch-to-batch variation. Syd Labs' recombinant anti-mouse CD8a YTS 169.4 is produced in mammalian cells, ensuring absolute sequence consistency. This advanced platform guarantees ultra-low endotoxin levels (<1 EU/mg), eliminating the non-specific toxicity often associated with classic hybridoma formats and providing pristine, publication-ready research datasets.
The standard method is to perform Flow Cytometry analysis on peripheral blood or spleen cell suspensions 24-48 hours after injection. Important: To accurately quantify the remaining T cells without competitive interference from the depleting YTS 169.4 antibody, you must use a different non-competing anti-CD8a clone (such as clone 53-6.7) for your fluorescent staining protocols.
In Vivo Grade Recombinant Anti-Mouse CD8a Monoclonal Antibodies (Clone YTS 169.4):
In Vivo Grade Recombinant Anti-Mouse CD8a Mouse IgG2a Monoclonal Antibody
In Vivo Grade Recombinant Anti-Mouse CD8a Mouse Fab Fragment
In Vivo Grade Recombinant Anti-Mouse CD8a Rat IgG2b Monoclonal Antibody
Syd Labs provides the following recombinant anti-human CD8a monoclonal antibodies:
In vivo grade recombinant anti-human CD8a antibodies (clone OKT8)
Recombinant anti-human CD8a antibodies (clone OKT8) for flow cytometry
Syd Labs provides the following recombinant anti-mouse CD8a monoclonal antibodies:
In vivo grade recombinant anti-mouse CD8a antibodies (clone 2.43)
In vivo grade recombinant anti-mouse CD8a antibodies (clone YTS 169.4)
In vivo grade recombinant anti-mouse CD8a antibodies (clone YTS 105.18)
Syd Labs provides the following recombinant anti-mouse CD8b monoclonal antibodies:
In vivo grade recombinant anti-mouse CD8b antibodies (clone YTS 156.7)
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