PA007545.m2a: In Vivo Grade Recombinant Anti-mouse CTLA-4 (CD152) Monoclonal Antibody (Clone: UC10-4F10-11), Mouse IgG2a Kappa

Recombinant mouse IgG2a Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: UC10-4F10-11) specifically binds to mouse CTLA-4 (CD152).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CTLA-4 (CD152) protein.

PA007545.hs: In Vivo Grade Recombinant Anti-mouse CTLA-4 (CD152) Monoclonal Antibody (Clone: UC10-4F10-11), Armenian hamster IgG

Recombinant hamster IgG Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: UC10-4F10-11) specifically binds to mouse CTLA-4 (CD152).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CTLA-4 (CD152) protein.

PA007380.m2b: In vivo Grade Recombinant Anti-mouse CTLA-4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: 9D9)

Recombinant Mouse IgG2b Monoclonal Antibody. 
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 9D9) specifically binds to the mouse CTLA-4 protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CTLA-4 protein.

PA007501.m2b: Recombinant Anti-mouse CTLA-4 Monoclonal Antibody (Clone: 9D9), Mouse IgG2b Kappa

Recombinant Mouse IgG2b Monoclonal Antibody.
Conjugation: Non-conjugated.
Specificity/Sensitivity: The recombinant 9D9 antibody specifically binds to mouse CTLA-4 protein.
Applications: Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F).

PA007501.h1Fs: Recombinant Anti-mouse CTLA-4 Monoclonal Antibody (Clone: 9D9), Human IgG1 Fc Silent Kappa

Recombinant human IgG1 Monoclonal Antibody with Fc silent mutation.
Conjugation: Non-conjugated.
Specificity/Sensitivity: The recombinant 9D9 antibody specifically binds to mouse CTLA-4 protein.
Applications: Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F).

BP005643: Biotinylated Human CTLA-4/CD152 Protein with the C-His-Avi Tag

Source: The recombinant Biotinylated Human CTLA-4/CD152 Protein, (amino acids Lys36-Asp161) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Biotinylated Human CTLA-4 protein with the C-His-Avi tag at 1 ug/ml (100 ul/well) on the streptavidin precoated plate (5 ug/ml). Dose response curve for the recombinant Human B7-1 protein with the C-hFc tag with the EC50 of 2.4 ng/ml determined by ELISA (QC Test).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

BP005158: Cynomolgus CTLA-4/CD152 Protein with the C-His Tag

Source: The recombinant Cynomolgus CTLA-4/CD152 Protein, (amino acids Ala37-Ser160) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Cynomolgus CTLA-4 protein with the C-His tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Anti-CTLA-4 Antibody protein with the C-hFc tag with the EC50 of 11.2 ng/ml determined by ELISA (QC Test). The affinity constant of 9.90 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

BP005332: Human CTLA-4/CD152 Protein with the C-His Tag

Source: The recombinant Human CTLA-4/CD152 Protein, (amino acids Lys36-Asp161) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human CTLA-4 protein with the C-His tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Anti-CTLA-4 Antibody protein with the C-hFc tag with the EC50 of 12.1 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

BP005051: Human CTLA-4/CD152 Protein with the C-hFc Tag

Source: The recombinant Human CTLA-4/CD152 Protein, (amino acids Lys36-Asp161) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human B7-2 protein with the C-hFc tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Human CTLA-4 protein with the C-hFc tag with the EC50 of 0.12 ug/ml determined by ELISA (QC Test). The affinity constant of 1.1nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

C050P: Ipilimumab Biosimilar, CTLA-4 Monoclonal Antibody

Recombinant Humanized IgG1 Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade ipilimumab biosimilar specifically binds to the human CTLA4.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by ipilimumab.

C037P: Tremelimumab Biosimilar, CTLA-4 monoclonal antibody

Recombinant Chimeric IgG2 Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade tremelimumab biosimilar specifically binds to the human protein receptor CD152 / CTLA4.
Applications: ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by tremelimumab.