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Home > Antibodies > Research-Grade Biosimilars > Ipilimumab Biosimilar, CTLA-4 Monoclonal Antibody

Ipilimumab Biosimilar, CTLA-4 Monoclonal Antibody

cytotoxic T-lymphocyte?associated antigen 4, cytotoxic T-lymphocyte antigen 4, CD152, CTLA4

Catalog No. Product Name Size List Price (US$) Quantity
C050P Ipilimumab Biosimilar, Human CTLA-4 Monoclonal Antibody 1 mg 175.00
C050P Ipilimumab Biosimilar, Human CTLA-4 Monoclonal Antibody 5 mg 600.00
C050P Ipilimumab Biosimilar, Human CTLA-4 Monoclonal Antibody 20 mg 1200.00
C050P.4S Ipilimumab Biosimilar, Human IgG4 S228P Mutant 0.5 mg 375.00
C050P.NA Ipilimumab Biosimilar, N297A Mutant 0.5 mg 375.00
C050P.LA Ipilimumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant 0.5 mg 375.00
Description

C050P: Ipilimumab Biosimilar, CTLA-4 Monoclonal Antibody

Recombinant fully human IgG1 monoclonal antibody.
Isotype: Human IgG1 kappa.
Source: The anti-human CTLA-4 monoclonal antibody ipilimumab biosimilar was produced in the ipilimumab biosimilar CHO stable cell line.
Specificity/Sensitivity: The in vivo grade ipilimumab biosimilar specifically binds to the human CTLA4.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by ipilimumab.
Form of Antibody: 0.2 uM filtered solution, pH 7.0, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The research grade ipilimumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Background

What is Ipilimumab biosimilar research grade? Ipilimumab is a human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.

Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule that competes with the stimulatory CD28 for binding to B7 on antigen presenting cells. CTLA-4 and CD28 are both presented on the surface of T-cells. Ipilimumab is a human IgG1 that binds CTLA-4, preventing the inhibition of T-cell mediated immune responses to tumors.

Syd Labs provides the following research grade anti-CTLA-4 antibody biosimilars:
Ipilimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody
Tremelimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody

PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. Syd Labs provides the following research grade anti-PD-L1 / PD-1 antibody biosimilar proteins:
Atezolizumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody
Avelumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody
Camrelizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody
Cemiplimab biosimilar, research grade, anti-human PD-1 monoclonal antibody
Durvalumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody
Nivolumab biosimilar, research grade, anti-human PD-1 monoclonal antibody
Pembrolizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody
Spartalizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody

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