BP005195: Biotinylated Human IL-17A/CTLA-8 Protein with the C-His-Avi Tag
Source: The recombinant Biotinylated Human IL-17A/CTLA-8 Protein, (amino acids Gly24-Ala155) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Biotinylated Human IL-17A protein with the C-His-Avi tag at 2 ug/ml (100 ul/well) on the streptavidin precoated plate (5 ug/ml). Dose response curve for the recombinant Human IL-17R alpha protein with the C-hFc tag with the EC50 of 18.2 ng/ml determined by ELISA (QC Test). The affinity constant of 2.18 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP005192: Biotinylated Mouse IL-17A/CTLA-8 Protein with the C-His-Avi Tag
Source: The recombinant Biotinylated Mouse IL-17A/CTLA-8 Protein, (amino acids Ala26-Ala158) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Mouse IL-17R alpha protein with the C-His-Avi tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Mouse IL-17A protein with the C-His tag with the EC50 of 28.3 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP005475: Cynomolgus IL-17A/CTLA-8 Protein with the C-His-Avi Tag
Source: The recombinant Cynomolgus IL-17A/CTLA-8 Protein, (amino acids Gly24-Ala155) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Cynomolgus IL-17A protein with the C-His-Avi tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Anti-IL-17A Antibody protein with the C-hFc tag with the EC50 of 4.4 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP005194: Human IL-17A/CTLA-8 Protein with the C-His Tag
Source: The recombinant Human IL-17A/CTLA-8 Protein, (amino acids Gly24-Ala155) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human IL-17A protein with the C-His tag at 2 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Human IL-17Rc protein with the C-hFc tag with the EC50 of 33.8 ng/ml determined by ELISA (Routine Test). The affinity constant of 1.57 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP005476: Mouse IL-17A/CTLA-8 Protein with the C-His-Avi Tag
Source: The recombinant Mouse IL-17A/CTLA-8 Protein, (amino acids Ala26-Ala158) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Mouse IL-17A protein with the C-His-Avi tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Mouse IL-17RA protein with the C-hFc tag with the EC50 of 122.6 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.C034P: Secukinumab Biosimilar, Human IL17A Monoclonal Antibody
Recombinant fully human IgG1 monoclonal antibody.
Specificity/Sensitivity: The monoclonal antibody Secukinumab biosimilar specifically binds to the human IL17A.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by Secukinumab.