BP005709: Biotinylated Human IL-6 R alpha/CD126 Protein with the C-His-Avi Tag
Source: The recombinant Biotinylated Human IL-6 R alpha/CD126 Protein, (amino acids Leu20-Pro365) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human IL-6 protein with the C-His-Avi tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Human IL-6 R alpha protein with the C-His tag with the EC50 of 0.78 ug/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP005001: Human IL-6 R alpha/CD126 Protein with the C-hFc Tag
Source: The recombinant Human IL-6 R alpha/CD126 Protein, (amino acids Leu20-Pro365) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human IL-6 protein with the C-hFc tag at 2 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Human IL-6 R alpha protein with the C-hFc tag with the EC50 6.0 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP005420: Human IL-6 R alpha/CD126 Protein with the C-His-Avi Tag
Source: The recombinant Human IL-6 R alpha/CD126 Protein, (amino acids Leu20-Pro365) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human IL-6 protein with the C-His-Avi tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Human IL-6 R alpha protein with the C-His tag with the EC50 of 0.15 ug/ml determined by ELISA (QC Test). The affinity constant of 0.22 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.C119P: Sarilumab Biosimilar, Human IL-6R Monoclonal Antibody
Recombinant Humanized IgG1 kappa Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade mepolizumab biosimilar specifically binds to the IL-6R protein.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by sarilumab.BP000172-CYT-286: Recombinant Human IL-6 Soluble Receptor
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 338 amino acids (20-357) corresponding to the mature IL-6R protein, having a molecular weight of 42.25 kDa, with an aminoterminal hexahistidine tag.
Purity > 90%, by SDS-PAGE and RP-HPLC.C032P: Tocilizumab Biosimilar, Anti-Human IL-6R Monoclonal Antibody
Recombinant Humanized IgG1 Monoclonal Antibody.
Specificity/Sensitivity: The in vivo grade tocilizumab biosimilar specifically binds to the human interleukin-6 receptor (IL-6R).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by tocilizumab.