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Home > Antibodies > Anti-Mouse Antibodies (In Vivo) > Anti-Mouse TCR-beta Monoclonal Antibodies

Anti-Mouse TCR-beta Monoclonal Antibodies

Tib; TCRbeta

Catalog No. Product Name Size List Price (US$) Quantity
PA007520.m2a In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda 1 mg 150.00
PA007520.m2a In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda 5 mg 350.00
PA007520.m2a In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda 25 mg 900.00
PA007520.hs In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Armenian hamster IgG 1 mg 150.00
PA007520.hs In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Armenian hamster IgG 5 mg 350.00
PA007520.hs In Vivo Grade Recombinant Anti-mouse TCR beta Monoclonal Antibody (Clone: H57-597), Armenian hamster IgG 25 mg 900.00
Description

PA007520.m2a: In Vivo Grade Recombinant Anti-mouse TCRβ Monoclonal Antibody (Clone: H57-597), Mouse IgG2a Lambda

Recombinant Mouse IgG2a Monoclonal Antibody.
Clone: H57-597.
Isotype: Mouse IgG2a Lambda.
Source: The anti-mouse TCRβ monoclonal antibody (clone: H57-597) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: H57-597) specifically binds to the mouse TCRβ.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCRβ protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Syd Labs provides the following recombinant anti-mouse TCRβ monoclonal antibodies for flow cytometry:
Recombinant Anti-mouse TCRβ monoclonal antibody (Clone: H57-597) for flow cytometry

References of Anti-Mouse TCR beta Monoclonal Antibody (Clone: H57-597)

Gonzalez, N. M., et al. Immunology. 2025 Feb;174(2):239-246. doi: 10.1111/imm.13881. PMID: 39648274
Here, we investigated the therapeutic potential of the anti-TCRβ (anti-mouse TCR beta H57-597) monoclonal antibody (anti-mouse TCR beta H57-597 mAb) (mAb) in a mouse model of SLE. ...Chronic T cell receptor (TCR) signalling induces T cell exhaustion, characterised by reduced capacity to induce tissue damage. ...T cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). ...Subsequently, mouse survival was monitored daily. ...Accordingly, MRL/lpr mice in the anti-TCRβ mAb group exhibited decreased proteinuria scores and minimal renal pathological damage compared to the PBS control group...
(Tags: anti-mouse TCR beta H57-597; anti-mouse TCR beta H57-597 mAb)
Ronghai Deng, et al. Transplantation. 2014 Jun 27;97(12):1216-24. doi: 10.1097/TP.0000000000000120. PMID: 24854475
T-cell response to islet allografts was potently abrogated by a brief treatment with an anti-TCRβ mAb (clone H57-597), resulting in long-term survival of BALB/c islet allografts in streptozotocin-induced diabetic B6 mice...
(Tags: anti-mouse TCR beta H57-597 antibody in vivo; anti-mouse TCR beta H57-597 antibody in animal model)
Aini Xie, et al. Endocrinology. 2017 Oct 1;158(10):3140-3151. doi: 10.1210/en.2016-1947. PMID: 28977608
These diabetic NOD mice were transiently treated with an anti-TCRβ chain (TCRβ) mAb, H57-597, for 5 days. Two weeks later, some NOD mice with established overt diabetes further received hepatic gene therapy using the islet-lineage determining gene Neurogenin3 (Ngn3), in combination with the islet growth factor gene betacellulin (Btc)...
(Tags: anti-mouse TCR beta antibody H57-597; clone H57-597 of anti-mouse TCR beta mAb)
For more technical references or data sheets regarding the Recombinant Anti-Mouse TCR beta Monoclonal Antibody (Clone: H57-597) formats, please contact our scientific support team at message@sydlabs.com.
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