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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Mouse IgG2a Monoclonal Antibody.
Clone: H57-597.
Isotype: Mouse IgG2a Lambda.
Source: The anti-mouse TCRβ monoclonal antibody (clone: H57-597) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: H57-597) specifically binds to the mouse TCRβ.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCRβ protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Syd Labs provides the following recombinant anti-mouse TCRβ monoclonal antibodies for flow cytometry:
Recombinant Anti-mouse TCRβ monoclonal antibody (Clone: H57-597) for flow cytometry
1、Transient Anti-TCRβ mAb Treatment Induces CD4 + T Cell Exhaustion and Prolongs Survival in a Mouse Model of Systemic Lupus Erythematosus.
Gonzalez, N. M., et al. Immunology. 2025 Feb;174(2):239-246. doi: 10.1111/imm.13881. PMID: 39648274
Here, we investigated the therapeutic potential of the anti-TCRβ (anti-mouse TCR beta H57-597) monoclonal antibody (anti-mouse TCR beta H57-597 mAb) (mAb) in a mouse model of SLE. ...Chronic T cell receptor (TCR) signalling induces T cell exhaustion, characterised by reduced capacity to induce tissue damage. ...T cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). ...Subsequently, mouse survival was monitored daily. ...Accordingly, MRL/lpr mice in the anti-TCRβ mAb group exhibited decreased proteinuria scores and minimal renal pathological damage compared to the PBS control group...
Tags: anti-mouse TCR beta H57-597; anti-mouse TCR beta H57-597 mAb
2、Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice
Ronghai Deng, et al. Transplantation. 2014 Jun 27;97(12):1216-24. doi: 10.1097/TP.0000000000000120.PMID: 24854475
T-cell response to islet allografts was potently abrogated by a brief treatment with an anti-TCRβ mAb (clone H57-597), resulting in long-term survival of BALB/c islet allografts in streptozotocin-induced diabetic B6 mice...
Tags: anti-mouse TCR beta H57-597 antibody in vivo; anti-mouse TCR beta H57-597 antibody in animal model
3、Anti-TCRβ mAb in Combination With Neurogenin3 Gene Therapy Reverses Established Overt Type 1 Diabetes in Female NOD Mice
Aini Xie, et al. Endocrinology. 2017 Oct 1;158(10):3140-3151. doi: 10.1210/en.2016-1947.PMID: 28977608
These diabetic NOD mice were transiently treated with an anti-TCR β chain (TCRβ) mAb, H57-597, for 5 days. Two weeks later, some NOD mice with established overt diabetes further received hepatic gene therapy using the islet-lineage determining gene Neurogenin3 (Ngn3), in combination with the islet growth factor gene betacellulin (Btc)...
Tags: anti-mouse TCR beta antibody H57-597; clone H57-597 of anti-mouse TCR beta mAb
For more references about anti-mouse TCR beta antibody (Clone: H57-597) please contact our scientific support team with message@sydlabs.com.
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