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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Recombinant Mouse IgG2a isotype controls, Recombinant Hamster IgG1 isotype controls and Recombinant Hamster IgG2 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant mouse IgG2a Monoclonal Antibody.
Clone: UC3-10A6.
Isotype: Mouse IgG2a kappa.
Source: The anti-mouse TCR V gamma 2 monoclonal antibody (clone: UC3-10A6) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: UC3-10A6) specifically binds to mouse TCR V gamma 2.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCR V gamma 2 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Recombinant hamster IgG Monoclonal Antibody.
Clone: UC3-10A6.
Isotype: Armenian hamster IgG Kappa.
Source: The anti-mouse TCR V gamma 2 monoclonal antibody (clone: UC3-10A6) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant hamster monoclonal antibody (clone: UC3-10A6) specifically binds to mouse TCR V gamma 2.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCR V gamma 2 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse TCR V gamma 2 monoclonal antibody of clone UC3-10A6 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
?? T cells control humoral immune response by inducing T follicular helper cell differentiation.
Rezende, R. M., et al. Nat Commun. 2018 Aug 8;9(1):3151. doi: 10.1038/s41467-018-05487-9. PMID: 30089795
Importantly, CXCR5 expression was only upregulated on V?1 ?? T cells after CFA immunization. ...To investigate the involvement of different subtypes of ?? T cells on their ability to control the humoral immune response, 200??g of anti-V?2 mAb (“anti-V?4”; UC3-10A6; BioXCell) or isotype control (BioXCell) were injected i.p. three days before either CFA or Alum immunization and three days before OVA booster dose. ...Consistent with the increased levels of OVA-specific immunoglobulins following V?4 ?? T cell depletion, we found that Tfh cell frequency was higher in V?4 ?? T cell-depleted mice than in isotype control (IC)-treated mice immunized with CFA/OVA, but not after Alum/OVA immunization. ...Importantly, TCR? ?/? mice transferred with CXCR5 ?/? ?? T cells had decreased Tfh cell frequencies and did not develop GC following CFA immunization as compared to mice transferred with WT ?? T cells. ...Thus, CXCR5 expression on ?? T cells is induced by ??TCR activation.
Tags: function of anti-mouse TCR V gamma 2 UC3-10A6 antibody; bioactivity of anti-mouse TCR V gamma 2 UC3-10A6
For more references about Anti-mouse TCR V gamma 2 Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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