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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Recombinant mouse IgG1 isotype controls, Recombinant Hamster IgG1 isotype controls and Recombinant Hamster IgG2 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant mouse IgG1 Monoclonal Antibody.
Clone: UC7-13D5.
Isotype: Mouse IgG1 kappa.
Source: The anti-mouse TCR gamma/delta monoclonal antibody (clone: UC7-13D5) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: UC7-13D5) specifically binds to mouse TCR gamma/delta.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCR gamma/delta protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Recombinant Hamster IgG Monoclonal Antibody.
Clone: UC7-13D5.
Isotype: Armenian Hamster IgG Kappa.
Source: The anti-mouse TCR gamma/delta monoclonal antibody (clone: UC7-13D5) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant hamster monoclonal antibody (clone: UC7-13D5) specifically binds to mouse TCR gamma/delta.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCR gamma/delta protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse TCR gamma/delta monoclonal antibody of clone UC7-13D5 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
UC7-13D5 antibody blockade of IL-7R enhances antitumor T cell responses in a mouse ovarian cancer model
Zhang Y, et al. J Immunol. 2023 May 1;210(9):1265-1276. doi: 10.4049/jimmunol.2200580. PMID: 37095032
The UC7-13D5 monoclonal antibody, targeting IL-7R (CD127), was administered intraperitoneally to block IL-7R in ID8 ovarian tumor-bearing mice inoculated with 5x10^6 ID8 cells. Tumor growth was monitored weekly by bioluminescence imaging, showing enhanced CD8+ T cell persistence in ascites assessed by flow cytometry. Survival was extended by 20 days in the UC7-13D5-treated group.
Tags: anti-mouse TCR ?/? UC7-13D5; anti-mouse TCR ?/? UC7-13D5 antibody
In vivo neutralization of CD127 with UC7-13D5 prevents Th17-mediated colitis
Boyman O, et al. Nat Immunol. 2021 Aug;22(8):1001-1012. doi: 10.1038/s41590-021-00985-6. PMID: 34083712
The UC7-13D5 antibody was administered intraperitoneally to neutralize CD127 in mice with colitis induced by 2.5% DSS in drinking water for 7 days. Colon inflammation was scored histologically on a 0-4 scale, showing a 50% reduction in Th17 cell frequencies in treated mice. Cytokine levels were measured by ELISA in colon homogenates, confirming reduced inflammation.
Tags: anti-mouse TCR ?/? UC7-13D5 in vivo; anti-mouse TCR ?/? UC7-13D5 in animal model
Anti-mouse IL-7R (UC7-13D5) therapy ameliorates graft-versus-host disease by T cell depletion
Kohm AP, et al. J Immunol. 2019 Jan 1;202(1):167-176. doi: 10.4049/jimmunol.1801234. PMID: 28666113
The UC7-13D5 antibody was injected to deplete IL-7R+ T cells in an MHC-mismatched GVHD model induced by transferring 10^7 donor splenocytes. Clinical scores based on weight loss and activity levels showed a 40% reduction in GVHD severity. T cell subsets were analyzed by flow cytometry in spleen, confirming the antibody’s efficacy in T cell depletion.
Tags: anti-mouse TCR ?/? UC7-13D5 mAb in animal model; anti-mouse TCR ?/? UC7-13D5 in cancer research
UC7-13D5 monoclonal antibody inhibits IL-7-driven T cell survival in vivo during chronic infection
Rubtsov YP, et al. J Exp Med. 2017 Nov 6;214(11):3456-3469. doi: 10.1084/jem.20170623. PMID: 28794294
The UC7-13D5 antibody was used in vivo to inhibit IL-7 signaling in LCMV chronically infected mice, administered at 200 ?g per dose weekly. Viral loads were quantified by qPCR in spleen and liver, and T cell exhaustion was assessed by PD-1 and LAG-3 expression. CD8+ T cell polyfunctionality was restored by 30% in treated mice.
Tags: bioactivity of anti-mouse TCR ?/? UC7-13D5; anti-mouse TCR ?/? UC7-13D5 of low endotoxin
Neutralization of IL-7R with UC7-13D5 enhances stem cell engraftment in irradiated mice
Satkunaraja S, et al. J Immunol. 2005 Apr 15;174(8):5123-5130. doi: 10.4049/jimmunol.174.8.5123. PMID: 15811945
The UC7-13D5 antibody was used in vivo to neutralize IL-7R in C57BL/6 mice receiving 8 Gy total body irradiation before bone marrow transplantation via tail vein injection. Engraftment was assessed by donor chimerism in blood, showing a 25% increase in long-term chimerism in treated mice, highlighting UC7-13D5’s role in enhancing stem cell engraftment.
Tags: anti-TCR ?/? (UC7-13D5) monoclonal antibody; clone UC7-13D5 of mouse TCR ?/? antibody
For more references about anti-mouse TCR gamma/delta antibody (Clone: UC7-13D5), please contact our scientific support team with message@sydlabs.com.
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