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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Recombinant mouse IgG1 isotype controls, Recombinant Hamster IgG1 isotype controls and Recombinant Hamster IgG2 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant mouse IgG1 Monoclonal Antibody.
Clone: UC7-13D5.
Isotype: Mouse IgG1 kappa.
Source: The anti-mouse TCR gamma/delta monoclonal antibody (clone: UC7-13D5) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: UC7-13D5) specifically binds to mouse TCR gamma/delta.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCR gamma/delta protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Recombinant Hamster IgG Monoclonal Antibody.
Clone: UC7-13D5.
Isotype: Armenian Hamster IgG Kappa.
Source: The anti-mouse TCR gamma/delta monoclonal antibody (clone: UC7-13D5) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant hamster monoclonal antibody (clone: UC7-13D5) specifically binds to mouse TCR gamma/delta.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse TCR gamma/delta protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse TCR gamma/delta monoclonal antibody of clone UC7-13D5 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment.
Benevides, L., et al. Cancer Res. 2015 Sep 15;75(18):3788-99. doi: 10.1158/0008-5472.CAN-15-0054. PMID: 26208902
We found that CD3+CD4+, CD3+CD8+, and CD3+??+ T cells produced IL17A and IFN? at all assessed points. ...In particular, we observed an increase in the number of IL17A-producing CD3+CD4+ and TCR??+ T cells at 25 and 35 dpi. ...To characterize the inflammatory infiltrate in the tumors, cells were isolated tissue as described in Supplementary Data. ...For T-cell analysis, antibodies to the following mouse proteins were obtained from BD Biosciences: CD3 (145-2C11), CD4 (RM4-5), CD8, (53?6.7), TCR ?? (UC7-13D5), IL17A (TC11-18H10), and IFN? (XMG1.2) or their respective isotype controls (BD Biosciences). ...For neutrophil analysis, antibodies to the following mouse proteins were obtained from Biolegend: CD11b (M1/70), F4/80 (BM8), MHCII (M5/114.15.2), Ly6G (1A8), and TNF? (MP6-XT22).
Tags: anti-mouse TCR gamma/delta UC7-13D5; anti-mouse TCR gamma/delta UC7-13D5 antibody
Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes.
Gillard, G. O., et al. PLoS Pathog. 2011 Aug;7(8):e1002141. doi: 10.1371/journal.ppat.1002141. PMID: 21829360
Ten days prior to a secondary vaccinia virus challenge we began administering isotype control antibodies or a cocktail of T cell- depleting monoclonal antibodies (clones GK1.5 (?CD4), H57?597 (?TCR?), and UC7-13D5 (?TCR??) ip to groups of na?ve and primed animals. ...The monoclonal antibody mixtures were administered every two weeks throughout the life of the experiment to maintain T cell depletion. ...The efficiency of T cell depletion was monitored by flow cytometric analysis of peripheral blood stained with a panel of monoclonal antibodies, including antibodies specific for CD3, TCR?, TCR??, and NK1.1. ...Representative flow cytometry plots from control and T cell-depleted mice 1 week post-challenge showed that the efficiency of T cell depletion was extremely high, greater than 99% as measured by percentage of CD3+ within the lymphocyte gate. ...Very few of those cells that fall within the CD3+ gate in the depleted mice showed staining for TCR?, TCR??, or CD8?; there are no masking antibodies to CD3 or CD8? present in the cocktail.
Tags: anti-mouse TCR gamma/delta UC7-13D5 in vivo; anti-mouse TCR gamma/delta UC7-13D5 in animal model
Murine and bovine ?? T cells enhance innate immunity against Brucella abortus infections.
Skyberg, J. A., et al. PLoS One. 2011 Jul;6(7):e21978. doi: 10.1371/journal.pone.0021978. PMID: 21765931
Third panel from top, cells were gated on ?? T cells (CD3+/TCR ??+) and assayed for IFN-? production. ...?? T cells were found to be the major producer of IL-17 during infection and were also found to produce IFN-?. ...Neutralization of ?? T cells enhanced the susceptibility of both wt and IL-17R? ?/? mice, and IL-17 receptor deficiency did not impact splenomegaly (Figure 3A), nor tissue colonization by B. ... Deficiency of either IFN-? or ?? T cells enhanced susceptibility to colonization by ?10-fold at one-week post-infection, while mice deficient in both IFN-? and ?? T cells possessed >300-fold more viable B. abortus in their spleens than did wt mice. ...Bovine ?? T cells could impair the intramacrophage replication of B.
Tags: anti-mouse TCR gamma/delta UC7-13D5 mAb in animal model; anti-mouse TCR gamma/delta UC7-13D5 in cancer research
For more references about Anti-mouse TCR gamma/delta Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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