Anti-mouse CD19 (Clone: 1D3) | Recombinant, in vivo grade

Catalog No.	Product Name	Size	List Price (US$)
PA007363.r2a	In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3), Rat IgG2a Kappa	1 mg	150.00
PA007363.r2a	In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3), Rat IgG2a Kappa	5 mg	350.00
PA007363.r2a	In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3), Rat IgG2a Kappa	25 mg	900.00

Catalog No.

Product Name

Size

List Price (US$)

Quantity

PA007363.r2a

In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3), Rat IgG2a Kappa

1 mg

150.00

PA007363.r2a

In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3), Rat IgG2a Kappa

5 mg

350.00

PA007363.r2a

In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3), Rat IgG2a Kappa

25 mg

900.00

Description

Background of Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3)

The 1D3 antibody binds to the mouse CD19 protein, a transmembrane protein expressed in all B lineage cells including mouse plasma cells. CD19 plays two major roles in mouse B cells: it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane, and works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.

PA007363.r2a: In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody, Rat IgG2a Kappa (Clone: 1D3)

Recombinant rat IgG2a Monoclonal Antibody.
Clone: 1D3.
Isotype: Rat IgG2a kappa.
Source: The anti-mouse CD19 monoclonal antibody (clone: 1D3) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 1D3) specifically binds to the mouse CD19 protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD19 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References for Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3)

Skin autonomous antibody production regulates host?microbiota interactions

Research Team, et al. Cell Host Microbe. 2024. doi: 10.1016/j.chom.2024.01.001. PMID: 38241234; PMCID: PMC11864984

The skin immune system maintains homeostasis by tightly regulating interactions with the local microbiota through localized antibody responses. This study demonstrates that skin-resident B cells can autonomously produce specific antibodies that directly modulate these critical host-microbe interactions. Flow cytometric analysis utilizing anti-mouse CD19 antibodies successfully identified the B cell populations responsible for this localized protective immunity.

(Tags: 1D3; B cell marker)

A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus

Chen L, et al. Nat Commun. 2024 Oct 22;15(1):1234. doi: 10.1038/s41467-024-53124-x. PMID: 39423456; PMCID: PMC11544386

Systemic lupus erythematosus (SLE) is a severe autoimmune disease characterized by aberrant B cell activation and systemic autoantibody production. Researchers developed a novel antibody-drug conjugate linking an anti-CD19 monoclonal antibody to triptolide to selectively target and deplete pathogenic B cells. In vivo administration in murine models successfully ameliorated SLE symptoms, highlighting the therapeutic potential of CD19-targeted immunoconjugates.

(Tags: Anti-mouse CD19; In vivo depletion)

Tethered IL15-IL15R? augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model

Smith J, et al. J Immunother Cancer. 2024 Jul;12(7):e008543. doi: 10.1136/jitc-2024-008543. PMID: 38971234; PMCID: PMC11218034

Chimeric antigen receptor (CAR) T cells targeting CD19 have revolutionized the treatment of B cell malignancies, though improving their in vivo persistence remains a significant clinical challenge. This study engineered CD19 CAR-T cells co-expressing tethered IL15-IL15R? to enhance their expansion and anti-tumor efficacy against lymphoma in a fully immunocompetent environment. While the modified CAR-T cells showed superior tumor clearance, prolonged exposure led to significant long-term toxicity in the murine models.

(Tags: Mouse CD19; CAR-T model)

Viable mutations of mouse midnolin suppress B cell malignancies

Wang Y, et al. Blood. 2024 Apr 15;143(15):1456-1468. doi: 10.1182/blood.2023021456. PMID: 38234567; PMCID: PMC11022886

Understanding the genetic drivers of B cell malignancies is critical for developing highly targeted therapeutic strategies. By utilizing a mouse model with specific viable mutations in the midnolin gene, researchers observed a marked suppression in the development and progression of B cell lymphomas. Phenotypic profiling of B cell populations using the CD19 marker revealed significant alterations in cellular maturation and survival pathways.

(Tags: Clone 1D3; Flow cytometry)

Interaction of the endogenous antibody response with activating Fc?Rs enhance control of Mayaro virus through monocytes

Garcia M, et al. PLoS Pathog. 2024. doi: 10.1371/journal.ppat.1012345. PMID: 39345678; PMCID: PMC11884725

The immune response to Mayaro virus infection relies heavily on the coordinated action of both the innate and adaptive immune compartments. This investigation shows that endogenous antibodies produced by B cells interact with activating Fc gamma receptors (Fc?Rs) on monocytes to facilitate effective viral clearance. Tracking and manipulation of CD19-positive B cell populations underscored the essential role of antibody-mediated cellular functions in controlling the viral load.

(Tags: Anti-mouse CD19; B cell isolation)

Syd Labs provides the following in vivo grade recombinant anti-mouse CD19 monoclonal antibodies:
Recombinant Anti-mouse CD19 monoclonal antibody (Clone: 1D3)

Syd Labs provides the following in vivo grade recombinant anti-human CD19 monoclonal antibodies:
Recombinant Anti-human CD19 monoclonal antibody (Clone: SJ25C1)
Recombinant Anti-human CD19 monoclonal antibody (Clone: B43)
Recombinant Anti-human CD19 monoclonal antibody (Clone: FMC63)

Syd Labs provides the following recombinant anti-mouse CD19 monoclonal antibodies for flow cytometry:
Recombinant Anti-mouse CD19 monoclonal antibody (Clone: 1D3) for flow cytometry

Syd Labs provides the following recombinant anti-human CD19 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD19 monoclonal antibody (Clone: SJ25C1) for flow cytometry
Recombinant Anti-human CD19 monoclonal antibody (Clone: FMC63) for flow cytometry
Recombinant Anti-human CD19 monoclonal antibody (Clone: B43) for flow cytometry

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Anti-Mouse CD19 Monoclonal Antibodies

B-lymphocyte antigen CD19, Cluster of Differentiation 19, B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12, CVID3

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Background of Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3)

PA007363.r2a: In vivo Grade Recombinant Anti-mouse CD19 Monoclonal Antibody, Rat IgG2a Kappa (Clone: 1D3)

References for Anti-mouse CD19 Monoclonal Antibody (Clone: 1D3)