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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant anti-mouse CD370 / CD47 bispecific antibodies share the variable region sequences with the rat anti-mouse CD370 antibody (clone number: 10B4) and the rat anti-mouse CD47 antibody (clone number: A4). The recombinant mouse IgG2c LALAPG bispecific isotype control antibody available.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background
The rat anti-mouse CD370 (Clec9A or DNGR-1) monoclonal antibody 10B4 (rat IgG2a kappa) reacts with the mouse CD370 protein. CLEC9A (C-type lectin domain family 9 member A), a transmembrane glycoprotein with a single extracellular C-type lectin domain (CTLD), plays a role in the immune response. As an activation receptor, CLEC9A is expressed on myeloid lineage cells, helps process material from dead cells, recognizes filamentous actin when cell membranes are damaged, and helps present antigens to cytotoxic T cells. CLEC9A has an intracellular cytoplasmic tail with potential signaling motifs. CLEC9A is expressed on a subset of BDCA3+ dendritic cells and CD16- monocytes in humans, and is expressed on CD8+ conventional DCs and plasmacytoid DCs in mice.
It is under investigation how the recombinant anti-mouse CD370 / CD47 bispecific antibodies (10B4 / A4) behave different from the individual monoclonal antibodies and their combination.
Our recombinant anti-mouse CD370 / CD47 bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse CD370 antibody (hybridoma clone name or number: 10B4) and the rat anti-mouse CD47 antibody (hybridoma clone name or number: A4).
The in vivo grade recombinant rat anti-mouse CD370 / CD47 bispecific antibody (mouse IgG2c LALAPG Kappa) was produced in mammalian cells.
Clone: 10B4, the same variable region sequences as the rat anti-mouse CD370 monoclonal antibody (clone number: 10B4). A4, the same variable region sequences as the rat anti-mouse CD47 monoclonal antibody (clone number: A4).
Isotype: mouse IgG2c, kappa.
Applications: immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.
Formulation: 0.2 μM filtered solution of 1x PBS.
Purity: >95% by SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.
Shipping: The in vivo grade recombinant rat anti-mouse CD370 / CD47 bispecific antibodies are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
3 month from date of receipt, 2 to 8°C as supplied.
12 months from date of receipt, -20°C to -70°C as supplied.
Recombinant anti-HEL / HEL Bispecific Isotype Control Antibodies:
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG1 Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2a Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2c Kappa Bispecific Isotype Control Antibody
Syd Labs provides the following anti-mouse CD370 and CD47 monoclonal antibodies:
In vivo grade recombinant anti-mouse CD370 monoclonal antibodies (Clone 10B4)
Recombinant anti-mouse CD370 monoclonal antibodies for flow cytometry (Clone 10B4)
Syd Labs provides the following anti-mouse CD370 / CD47 bispecific antibodies:
In vivo grade recombinant anti-mouse CD370 / CD47 bispecific antibodies (Clone 10B4 / A4)
Syd Labs provides the following anti-human CD370 and CD47 monoclonal antibodies:
In vivo grade recombinant anti-human CD47 monoclonal antibodies (Clone B6H12)
Recombinant anti-human CD47 monoclonal antibodies for flow cytometry (Clone B6H12)
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