PA007274.r2a: In vivo Grade Recombinant Anti-mouse CD40 Monoclonal Antibody, Rat IgG2a Kappa (Clone: FGK4.5)

Recombinant rat IgG2a Monoclonal Antibody. 
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: FGK4.5) specifically binds to the mouse CD40 protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD40 protein.

PA007274.m2a: In vivo Grade Recombinant Anti-mouse CD40 Monoclonal Antibody, Mouse IgG2a Kappa (Clone: FGK4.5)

Recombinant mouse IgG2a Monoclonal Antibody. 
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: FGK4.5) specifically binds to the mouse CD40 protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD40 protein.

PA007380.m2b: In vivo Grade Recombinant Anti-mouse CTLA-4 Monoclonal Antibody, Mouse IgG2b Kappa (Clone: 9D9)

Recombinant Mouse IgG2b Monoclonal Antibody. 
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 9D9) specifically binds to the mouse CTLA-4 protein.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CTLA-4 protein.

PA007169.m2a: In Vivo Grade Recombinant Anti-Mouse GITR Mouse IgG2a Lambda Monoclonal Antibody

The in vivo grade recombinant anti-mouse GITR mouse IgG2a monoclonal antibody (clone of DTA-1) was produced in mammalian cells.
Applications: Western blot, immunoprecipitation (IP), Flow Cytometry (FC), and various in vitro and in vivo functional assays.

PA007169.r2b: In Vivo Grade Recombinant Anti-Mouse GITR Rat IgG2b Lambda Monoclonal Antibody

The in vivo grade recombinant anti-mouse GITR rat IgG2b monoclonal antibody (clone of DTA-1) was produced in mammalian cells.
Applications: Western blot, immunoprecipitation (IP), Flow Cytometry (FC), and various in vitro and in vivo functional assays.

Fast turnaround: 8-10 weeks in total. Our antibody humanization process involves significant computational analysis, and thus is quite efficient and requires much less trial time.

A human antibody database and a proprietary method are used for analysis and design of humanized antibodies.

Nine humanized antibodies (each combination of 3 designed heavy chains and 3 designed light chains) are constructed and produced for antigen binding confirmation and affinity measurement.

BP004932: Biotinylated Human IL-1 Beta/IL-1F2 Protein with the C-His-Avi Tag

Source: The recombinant Biotinylated Human IL-1 Beta/IL-1F2 Protein, (amino acids Ala117-Ser269) fused with a His-Avi tag at the C-terminus, was produced in E.coli cells.
Activity: Immobilized recombinant Human IL-1R2 protein with the C-His-Avi tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Human IL-1 Beta protein with the C-His tag with the EC50 of 13.1 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

BP005753: Biotinylated Human IL-1 Rrp2/IL-1 R6 Protein with the C-His-Avi Tag

Source: The recombinant Biotinylated Human IL-1 Rrp2/IL-1 R6 Protein, (amino acids Asp20-Arg335) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Anti-IL-1 Rrp-2 Antibody protein with the C-His-Avi tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Biotinylated Human IL-1 Rrp2 protein with the C-His tag with the EC50 of 46.5 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

BP005646: Biotinylated Human IL-1R3/IL-1 RAcP Protein with the C-His-Avi Tag

Source: The recombinant Biotinylated Human IL-1R3/IL-1 RAcP Protein, (amino acids Ser21-Glu359) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Biotinylated Human IL-1R3 protein with the C-His-Avi tag at 0.5 ug/ml (100 ul/well) on the streptavidin precoated plate (5 ug/ml). Dose response curve for the recombinant Anti-IL-1R3 Antibody protein with the C-hFc tag with the EC50 of 2.4 ng/ml determined by ELISA.
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

BP004199: Biotinylated Human SOST/Sclerostin Protein with the N-His-Avi Tag

Source: The recombinant Biotinylated Human SOST/Sclerostin Protein, (amino acids Gln24-Tyr213) fused with a His-Avi tag at the N-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Anti-SOST Antibody protein with the N-His-Avi tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Human SOST protein with the N-His tag with the EC50 of 9.6 ng/ml determined by ELISA (QC Test).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.

BP002641-CG19: Recombinant Human Caspase-14 (CASP14) Enzyme

Source: E. coli-derived.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).

BP003933: Cynomolgus IL-1 alpha/IL-1A Protein with the C-His Tag

Source: The recombinant Cynomolgus IL-1 alpha/IL-1A Protein, (amino acids Ser113-Ala271) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity:
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.