BP003875: Cynomolgus PCSK9 Protein with the C-His Tag
Source: The recombinant Cynomolgus PCSK9 Protein, (amino acids Glu151-Gln811) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Cynomolgus PCSK9 protein with the C-His tag at 5 ug/ml (100 ul/Well) on the plate. Dose response curve Anti-PCSK9 Antibody protein with the C-hFc tag with the EC50 of 55.7 ng/ml determined by ELISA (QC Test). The affinity constant of 0.27 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.C105P: Evolocumab Biosimilar, PCSK9 Monoclonal Antibody
Recombinant fully human IgG2 monoclonal antibody.
Specificity/Sensitivity: The monoclonal antibody evolocumab biosimilar specifically binds to the human PCSK9.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by evolocumab.BP005358: Human PCSK9 Protein with the C-His Tag
Source: The recombinant Human PCSK9 Protein, (amino acids Gln31-Gln692) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: Immobilized recombinant Human PCSK9 protein with the C-His tag at 2 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Anti-PCSK9 antibody protein with the C-hFc tag with the EC50 of 0.16 ug/ml determined by ELISA (QC Test). The affinity constant of 0.35 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP004518: Mouse PCSK9 Protein with the C-His Tag
Source: The recombinant Mouse PCSK9 Protein, (amino acids Gln35-Gln694) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Activity: The affinity constant of 0.61 nM as determined in SPR assay (Biacore T200).
Purity: >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU per ug of protein as determined by LAL method.BP001728-CA83: Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein
Source: HEK 293-derived.
Purity: >95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).BP001728-CA87: Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein
Source: HEK 293-derived.
Purity: >95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).