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Conditions of optimal HSF1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
The transcription of heat-shock genes is rapidly induced after temperature stress in response to environmental changes, and it is also involved in oogenesis, spermatogenesis, and placental development. Known for its participation in heat shock response, the HSF1 protein regulates the transcription of hundreds of targets, such as genes involved in protein folding, detoxification, energy generation, carbohydrate metabolism, and cell wall organization. HSF1 binds to MTA1 in vitro & in breast carcinoma. Suppression of estrogen-dependent transcription may contribute to role of HSF1 in cancer. Human cancer lines of diverse origins express higher dependence on HSF1 function to maintain proliferation and survival than their non-transformed counterparts. HSF1 induces anticoagulation and relaxation factors in vascular endothelial cells and could therefore be used to treat cardiovascular disease. HSF1 is directly involved in the regulation of HO1 having an anti-oxidative role. NF-kappaB and HSF1 are systemically activated in human acute pancreatitis. HSF1 activation protects against severity of pancreatitis. HSF is a vital transcription factor which plays a role in up-regulation of VDUP1 expression through stresses such as elevated density and serum deprivation cultures.
BP001992-HSP-017: Recombinant Human Heat Shock Transcription Factor-1 (HSF1) Protein
Source: E. coli-derived.
The recombinant HSF1 protein is a single, non-glycosylated polypeptide chain containing 549 amino acids and having a molecular mass of 59 kDa. The recombinant HSF1 protein is fused to His-Tag at N-terminus.
Purity: > 75.0% as determined by RP-HPLC and SDS-PAGE.
Formulation: The HSF1 protein (1 mg/ml) contains 20 mM Tris pH-8, 50 mM NaCl and 1 mM DTT.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
HSF1 Antibodies:
HSF1 Polyclonal Antibody
HSF1 Monoclonal Antibody
HSF1 (Phospho-Thr142) Polyclonal Antibody
HSF1 (Phospho-Ser303) Polyclonal Antibody
HSF1 (Phospho-Ser121) Polyclonal Antibody
HSF1 (Ab-303) Polyclonal Antibody
HSF1 (Ab-142) Polyclonal Antibody
HSF1 (Ab-121) Polyclonal Antibody
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