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GONAL F Biosimilar Stable Cell Line

Follitropin Alfa, Recombinant Human Follicle Stimulating Hormone, FSH

Catalog No. Product Name Size List Price (US$) Quantity
C014 GONAL F Biosimilar Stable Cell Line 1 package Request

GONAL-F, recombinant human FSH, is used for infertility therapy, mainly for ovarian hyperstimulation as part of IVF. Follicle-stimulating hormone (FSH), synthesized and secreted by gonadotrophs of the anterior pituitary gland, regulates the development, growth, pubertal maturation, and reproductive processes of human and other animal bodies. FSH and luteinizing hormone (LH) act synergistically in reproduction. The structure of FSH is similar to those of LH, thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, named as alpha and beta subunits. The alpha subunits of LH, FSH, TSH, and hCG are identical, containing 92 amino acids. Their beta subunits vary. The FSH beta subunit confers its specific biologic action and is responsible for interaction with the FSH-receptor. FSH is a glycoprotein. Only if there is sugar modification on each monomeric subunit, the protein is functional. The sugar attached consists of fucose, galactose, mannose, galactosamine, glucosamine, and sialic acid, which is critical for its biologic half-life of 3–4 hours.

C014: GONAL-F Biosimilar Stable Cell Line (CHO)

The yield of GONAL-F biosimilar from the CHO stable cell line was above 750 mg/L in a 15 liter manufacturing.

The GONAL-F stable cell line alone can be transferred alone or together with the technology of process development and/or antibody purification.

Syd Labs also provides the following hormone biosimilar stable cell lines:
Luveris Biosimilar Stable Cell Line (luteinizing hormone, LH)
Thyrogen Biosimilar Stable Cell Line (thyroid-stimulating hormone, TSH)
Ovidrel Biosimilar Stable Cell Line (human chorionic gonadotropin, hCG)

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