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Luveris Biosimilar Stable Cell Line

Lutropin Alfa, Recombinant Human Luteinizing Hormone, rhLH

Catalog No. Product Name Size List Price (US$) Quantity
C024 Luveris Biosimilar Stable Cell Line 1 package Request

Lutropin alfa (trade name Luveris), the recombinant LH,  can be used in infertility therapy to stimulate follicular development in IVF therapy. Luteinizing hormone (LH, lutropin, lutrophin, interstitial cell-stimulating hormone or ICSH in males), produced by gonadotroph cells in the anterior pituitary gland, triggers ovulation and development of the corpus luteum in females and stimulates Leydig cell production of testosterone in males. The structure of LH is similar to those of Follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, named as alpha and beta subunits. The alpha subunits of LH, FSH, TSH, and hCG are identical, containing 92 amino acids. Their beta subunits vary. The LH beta subunit (LHB) with 120 amino acids is responsible for the specific interaction with the LH receptor. Because an amino acid sequence in LHB shares large homologies with that in the beta subunit of hCG, both LH and hCG stimulate the same receptor. Because of the different composition of their sugar moieties in their beta subunits, the biologic half-life of LH is 20 minutes only, much shorter than that of FSH (3–4 hours) and hCG (24 hours). LH acts synergistically with FSH.

C024: Luveris Biosimilar Stable Cell Line (CHO)

The yield of Luveris biosimilar from the CHO stable cell line was above 100 mg/L in flask.

The Luveris Biosimilar stable cell line alone can be transferred alone or together with the technology of process development and/or antibody purification.

Syd Labs also provides the following hormone biosimilar stable cell lines:
GONAL F Biosimilar Stable Cell Line (follicle-stimulating hormone, FSH)
Thyrogen Biosimilar Stable Cell Line (thyroid-stimulating hormone, TSH)
Ovidrel Biosimilar Stable Cell Line (human chorionic gonadotropin, hCG)

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