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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal FGF21 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation, or following the ingestionof a highly-fat/low-carbohydrate diet.Upon FGF21 secretion, white adipose tissue is induced to release free fatty acids from triglyceride stores. Once free fatty acid reach hepatocytes, they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies, release, and transported to peripheral tissue for TCA processing and energy generation.
BP000020-CYT-281: Recombinant Human Fibroblast Growth Factor 21 (FGF 21) Protein, His Tag
Source: E coli-derived.
A single, non-glycosylated, polypeptide chain containing 202 amino acids (29-209) and having a molecular mass of 21.6 kDa.
Measured in a cell proliferation assay using NIH-3T3 cells. The ED50 for this effect is < 12 ug/ml, which corresponds to > 83,000 units/ml.
Purity: > 90.0% by SDS-PAGE.
Formulation: The FGF-21 His tag protein solution in 20 mM Tris-HCL buffer pH-8 and 10% glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other FGF21 Proteins:
Recombinant Rat FGF21 Protein
Recombinant Mouse FGF21 Protein, His Tag
Recombinant Mouse FGF21 Protein
Recombinant Human FGF21 Protein
Recombinant Human FGF21 Protein
Recombinant Bovine FGF21 Protein
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