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Home > Antibodies > Anti-Mouse Antibodies (In Vivo) > Anti-Mouse PD-1 / VEGFR-2 Bispecific Antibodies

Anti-Mouse PD-1 / VEGFR-2 Bispecific Antibodies

PD-1 / VEGFR2 Bispecific, PD1 / VEGFR-2 Bispecific, VEGFR-2 / PD-1 Bispecific, VEGFR2 / PD-1 Bispecific

Catalog No. Product Name Size List Price (US$) Quantity
PA008026.m2cLA In Vivo Grade Recombinant Anti-mouse PD-1 / VEGFR-2 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / DC101) 5 mg 595.00
PA008026.m2cLA In Vivo Grade Recombinant Anti-mouse PD-1 / VEGFR-2 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / DC101) 25 mg 1750.00
Description

Background

The rat anti-mouse PD-1 monoclonal antibody (clone No. RMP1-14, rat IgG2a kappa) reacts with the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The RMP1-14 antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein.

It is under investigation how the recombinant anti-mouse PD-1 / VEGFR-2 bispecific antibodies (RMP1-14.1 / DC101) behave different from the individual monoclonal antibodies and their combination.

Our recombinant anti-mouse PD-1 / VEGFR-2 bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14) and the rat anti-mouse VEGFR-2 antibody (hybridoma clone name or number: DC101).

PA008026.m2cLA: In Vivo Grade Recombinant Anti-mouse PD-1 / VEGFR-2 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / DC101)

The in vivo grade recombinant anti-mouse PD-1 / VEGFR-2 bispecific antibody (mouse IgG2c LALAPG kappa) was produced in mammalian cells. 
Clone: RMP1-14.1, the same variable region sequences as the rat anti-mouse PD-1 monoclonal antibody (clone number: RMP1-14). DC101, the same variable region sequences as the rat anti-mouse VEGFR-2 monoclonal antibody (clone number: DC101).
Isotype: mouse IgG2c, kappa.
Applications: immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.
Formulation: 0.2 μM filtered solution of 1x PBS.
Purity: >95% by SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

Shipping: The in vivo grade recombinant rat anti-mouse PD-1 / VEGFR-2 bispecific antibodies are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
3 month from date of receipt, 2 to 8°C as supplied.
12 months from date of receipt, -20°C to -70°C as supplied.

Recombinant anti-HEL / HEL Bispecific Isotype Control Antibodies:
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG1 Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2a Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2c Kappa Bispecific Isotype Control Antibody

Syd Labs provides the following anti-mouse PD1 (PD-L1) and VEGFR2 monoclonal antibodies:
In vivo grade recombinant anti-mouse PD-1 monoclonal antibodies (Clone RMP1-14.1)
In vivo grade recombinant anti-mouse PD 1 monoclonal antibodies (Clone 29F.1A12.1)
In vivo grade recombinant anti-mouse PD-L1 monoclonal antibodies (Clone 10F.9G2.1)
In vivo grade recombinant anti-mouse VEGFR2 monoclonal antibodies (Clone DC101)

Syd Labs provides the following anti-mouse PD-1 / VEGFR-2 bispecific antibodies:
In vivo grade recombinant anti-mouse PD 1 / VEGFR2 bispecific antibodies (Clone RMP1-14.1 / DC101)
In vivo grade recombinant anti-mouse PD-1 / VEGFR-2 bispecific antibodies (Clone 29F.1A12.1 / DC101)

Syd Labs provides the following anti-mouse PD-L1 / VEGFR-2 bispecific antibodies:
In vivo grade recombinant anti-mouse PDL1 / VEGFR-2 bispecific antibodies (Clone 10F.9G2.1 / DC101)

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