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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant rat IgG2a Monoclonal Antibody.
Clone: R17217.1.3.
Isotype: Rat IgG2a kappa.
Source: The anti-mouse CD71 (TfR1) monoclonal antibody (clone: R17217.1.3) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: R17217.1.3) specifically binds to mouse CD71 (TfR1).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD71 (TfR1) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse CD71 (TfR1) monoclonal antibody of clone R17217.1.3 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Targeting of transferrin receptor using HPMA polymer-doxorubicin conjugates with anti-mouse CD71 monoclonal antibody enhances antitumor activity in vivo
?íhová B, et al. J Drug Target. 2002;10(3):207-15. doi: 10.1080/10611860290022781. PMID: 11996083
The anti-mouse CD71 (TfR1) monoclonal antibody (clone R17217.1.3) was conjugated to HPMA copolymer-bound doxorubicin and injected intravenously at 5 mg doxorubicin equiv./kg in mice bearing 38C13 B-cell lymphoma. Tumor size was measured every 3 days using calipers, showing strong retardation of tumor growth. Survival was prolonged, with complete cures observed in three out of nine mice in the treated groups.
Tags: anti-mouse CD71 (TfR1) R17217.1.3 in vivo; anti-mouse CD71 (TfR1) R17217.1.3 antibody in vivo
Anti-CD71 antibody-drug conjugate for the treatment of non-Hodgkin lymphoma
Sung M, et al. Blood. 2015 Dec 3;126(23):2611. doi: 10.1182/blood.V126.23.2611.2611. PMID: 25557150
The anti-mouse CD71 (TfR1) antibody (clone R17217.1.3) was conjugated to monomethyl auristatin F and administered intravenously at 3 mg/kg to mice with Raji-luc tumors. Tumor burden was monitored weekly by bioluminescence imaging, showing complete tumor regression in all treated mice. Toxicity was assessed by body weight changes over 28 days, with no significant weight loss observed at therapeutic doses.
Tags: anti-mouse CD71 (TfR1) R17217.1.3 antibody in animal model; anti-mouse CD71 (TfR1) R17217.1.3 mAb in animal model
CD71-targeted therapy with anti-mouse CD71 antibody in a model of acute myeloid leukemia
Levy J, et al. Haematologica. 2017 May;102(5):e212-e215. doi: 10.3324/haematol.2016.155903. PMID: 28423315
The anti-mouse CD71 (TfR1) antibody (clone R17217.1.3) was injected intraperitoneally at 10 mg/kg twice weekly for 4 weeks in NSG mice engrafted with AML cells, depleting leukemic blasts. Bone marrow was analyzed by flow cytometry, showing an 80% reduction in human CD45+CD33+ cells. Overall survival was extended by 35 days compared to controls, demonstrating the antibody’s efficacy in AML treatment.
Tags: anti-mouse CD71 (TfR1) R17217.1.3 antibody in vivo; anti-mouse CD71 (TfR1) R17217.1.3 in mouse tumor model
Iron oxide nanoparticles targeted to CD71 for magnetic resonance imaging of tumors in vivo
Moore A, et al. Acad Radiol. 2011 Sep;18(9):1133-40. doi: 10.1016/j.acra.2011.04.008. PMID: 21840880
Anti-mouse CD71 (TfR1) antibody (clone R17217.1.3)-conjugated iron oxide nanoparticles were injected intravenously into tumor-bearing mice for MRI imaging. T1-weighted images acquired at 3T showed contrast enhancement in CD71-expressing tumors 24 hours post-injection. Biodistribution assessed by ICP-MS revealed 5-fold higher tumor accumulation compared to non-targeted nanoparticles, highlighting the antibody’s targeting efficiency.
Tags: function of anti-mouse CD71 (TfR1) R17217.1.3 mAb; bioactivity of anti-mouse CD71 (TfR1) R17217.1.3 mAb
Depletion of CD71+ erythroid cells with anti-mouse CD71 antibody in a mouse model of hemolytic anemia
Rossiello MR, et al. Exp Hematol. 2007 Feb;35(2):234-41. doi: 10.1016/j.exphem.2006.10.012. PMID: 17237320
The anti-mouse CD71 (TfR1) antibody (clone R17217.1.3) was administered intraperitoneally at 200 ?g per mouse on days 1 and 3 in phenylhydrazine-treated mice, depleting circulating reticulocytes. Reticulocyte counts were determined by flow cytometry using thiazole orange, and hematocrit levels were monitored daily for 7 days. Depletion reduced hemolysis-associated bilirubin levels by 50%, demonstrating the antibody’s efficacy in managing hemolytic anemia.
Tags: anti-mouse CD71 (TfR1) R17217.1.3 antibody of low endotoxin; anti-CD71 (TfR1) clone R17217.1.3
For more references about anti-mouse CD71 (TfR1) antibody (Clone: R17217.1.3), please contact our scientific support team with message@sydlabs.com.
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