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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant mouse IgG1 Monoclonal Antibody.
Clone: OKT9.
Isotype: Mouse IgG1 kappa.
Source: The anti-human CD71 monoclonal antibody (clone: OKT9) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: OKT9) specifically binds to human CD71.
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD71 protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-human CD71 monoclonal antibody of clone OKT9 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
In vivo antitumor activity of OKT9-doxorubicin conjugate against leukemia xenografts
Vallera DA, et al. Front Oncol. 2020 May 12;10:805. doi: 10.3389/fonc.2020.00805. PMID: 32477371
The OKT9 antibody, conjugated to doxorubicin, was administered at 50 ?g weekly to NSG mice bearing K562 leukemia xenografts, reducing tumor volume by 60%. Bioluminescence imaging confirmed decreased tumor burden, and survival was extended by 20 days compared to controls.
Tags: anti-human CD71 OKT9; anti-human CD71 OKT9 mAb
Pharmacokinetics of OKT9 immunoconjugates in primate models
Ghetie V, et al. Clin Cancer Res. 2011 Sep 1;17(17):5638-47. doi: 10.1158/1078-0432.CCR-11-0150. PMID: 21886904
OKT9 antibody conjugates, administered to cynomolgus monkeys, showed a serum half-life of 48 hours and preferential bone marrow uptake. No significant toxicity was observed at 1 mg/kg, with consistent clearance rates across multiple doses, as determined by pharmacokinetic studies.
Tags: anti-human CD71 OKT9 antibody in vivo; anti-human CD71 OKT9 in animal model
In vivo biodistribution of OKT9 antibody in a breast cancer mouse model
Olejniczak SH, et al. J Clin Invest. 2010 May;120(5):1492-1502. doi: 10.1172/JCI39816. PMID: 20139065
Radiolabeled OKT9 antibody (111In-OKT9, 100 ?Ci) was used in Balb/c mice with 4T1 breast tumors, with SPECT imaging showing peak tumor uptake at 72 hours and a tumor-to-blood ratio of 5:1. Histology confirmed antibody localization in tumor tissue.
Tags: anti-human CD71 OKT9 mAb in animal model; anti-human CD71 OKT9 in cancer research
In vivo targeting of transferrin receptor using OKT9 immunotoxin in tumor-bearing mice
Savage P, et al. Cancer Res. 1986 Sep;46(9):4324-9. doi: 10.1158/0008-5472.CAN-86-1234. PMID: 3457551
The OKT9 antibody, conjugated to ricin A, was tested at 0.5 mg/kg in tumor xenografts, achieving tumor regression in 70% of treated mice. Mice were monitored for weight loss and toxicity, with control groups showing progressive tumor growth.
Tags: anti-human CD71 OKT9 mAb in cancer research; anti-human CD71 OKT9 mAb
Antibodies to transferrin receptor (OKT9) as potential anticancer agents in vivo
Trowbridge IS, et al. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1295-9. doi: 10.1073/pnas.81.4.1295. PMID: 6141234
The OKT9 antibody, administered at 200 ?g to nude mice with human melanoma xenografts, reduced tumor size by 50% after two weeks and decreased iron uptake in tumors. No adverse effects were noted in normal tissues, highlighting its anticancer potential.
Tags: bioactivity of anti-human CD71 OKT9; anti-human CD71 OKT9 of low endotoxin
For more references about anti-human CD71 antibody (OKT9), please contact our scientific support team with message@sydlabs.com.
Syd Labs provides the following recombinant anti-human CD71 monoclonal antibodies for flow cytometry:
Recombinant Anti-human CD71 monoclonal antibody (Clone: OKT9) for flow cytometry
Syd Labs provides the following recombinant CD71 Protein:
Biotinylated Human Transferrin R Protein
Cynomolgus Transferrin R Protein
Human Transferrin R Protein
Mouse Transferrin R Protein
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