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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant rat IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant rat IgG2a Monoclonal Antibody.
Clone: GR-20.
Isotype: Rat IgG2a kappa.
Source: The anti-mouse CD119 (IFN gamma R1) monoclonal antibody (clone: GR-20) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: GR-20) specifically binds to mouse CD119 (IFN gamma R1).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse CD119 (IFN gamma R1) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-mouse CD119 (IFN gamma R1) monoclonal antibody of clone GR-20 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage.
Vicetti Miguel, R. D., et al. PLoS One. 2016 Sep 8;11(9):e0162445. doi: 10.1371/journal.pone.0162445. PMID: 27606424
Where indicated, mice were injected i.p. with 100 ?g of a CD4-depleting antibody (clone GK1.5), 100 ?g of a CD8?-depleting antibody (clone 2.43), 200 ?g of an IFN-? blocking antibody (clone XMG1.2) concomitant with 200 ?g of an IFN-? receptor 1 (CD119) blocking antibody (clone GR-20), or 200 ?g of an IL-17 blocking antibody (clone 17F3) (all antibodies from BioXCell, West Lebanon, NH). ...Chlamydia trachomatis, the most common sexually transmitted bacterium, is exclusively a pathogen of humans. ...The best accepted and explored strategy for developing such a vaccine is based on results from mouse models of genital Chlamydia muridarum infection in which protection against secondary infection is conferred by Chlamydia-specific TH1-type immunity. ...Phenotypic disease expression in women with genital C. trachomatis infection is rare, but can have devastating consequences for reproductive fertility. ...We collected cervicovaginal lavages (CVL) at various days post infection (dpi) to quantify levels of infectious C. ...As mice were protected against ivag challenge infection by CD4+ T cells, we sought to define T cell responses in these animals. For this, iliac lymph nodes were excised from Balb/cJ mice at 5 dpc, processed into single-cell suspensions, and stimulated with inactivated C.
Tags: anti-mouse CD119 (IFN gamma R1) GR-20; anti-mouse CD119 (IFN gamma R1) GR-20 mAb
Aberrant innate immune activation following tissue injury impairs pancreatic regeneration.
Folias, A. E., et al. PLoS One. 2014 Jul 10;9(7):e102125. doi: 10.1371/journal.pone.0102125. PMID: 25010227
The following antibodies were used for antibody depletion experiments: ?-IFN?R (GR-20), Rat IgG2a (2A3) (University of California at San Francisco Monoclonal Antibody Core; Bio-X-Cell). ...Mice received i.p. injections of 0.5 mg of ?- IFN?R (GR-20) and Rat IgG2a (2A3) isotype control every other day. ...IFN? was performed as suggested by the manufacturer (eBioscience). ...(A) Caerulein injection regime, time of tissue harvesting and schematic depiction of acinar de-differentiation and regeneration following caerulein-induced injury in WT mice. ...While the majority of the pancreas is affected in both genotypes at CaeD2, the pancreas of Rag1?/? mice at CaeD7 is composed of variable regions of either normal or damaged tissue.
Tags: anti-mouse CD119 (IFN gamma R1) GR-20 antibody in vivo; anti-mouse CD119 (IFN gamma R1) GR-20 in animal model
For more references about Anti-mouse CD119 (IFN gamma R1) Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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