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Home > Antibodies > Anti-Mouse Antibodies for Flow Cytometry > Anti-Mouse CD115 Monoclonal Antibodies for Flow Cytometry

Anti-Mouse CD115 Monoclonal Antibodies for Flow Cytometry

Colony Stimulating Factor 1 Receptor, CSF1R, Macrophage Colony-stimulating Factor Receptor, M-CSFR

Catalog No. Product Name Size List Price (US$) Quantity
PA007484.r2a Recombinant Anti-mouse CSF1R (CD115) Monoclonal Antibody (Clone: AFS98), Rat IgG2a Kappa 100 ug 90.00
PA007484.r2a Recombinant Anti-mouse CSF1R (CD115) Monoclonal Antibody (Clone: AFS98), Rat IgG2a Kappa 500 ug 120.00
PA007484.h1Fs Recombinant Anti-mouse CSF1R (CD115) Monoclonal Antibody (Clone: AFS98), Human IgG1 Fc Silent Kappa 100 ug 180.00
PA007484.h1Fs Recombinant Anti-mouse CSF1R (CD115) Monoclonal Antibody (Clone: AFS98), Human IgG1 Fc Silent Kappa 500 ug 240.00
PA007716.h1Fs-b Biotinylated Recombinant Anti-mouse CSF1R (CD115) Monoclonal Antibody (Clone: AFS98), Human IgG1 Fc Silent Kappa 100 ug 135.00
PA007716.h1Fs-b Biotinylated Recombinant Anti-mouse CSF1R (CD115) Monoclonal Antibody (Clone: AFS98), Human IgG1 Fc Silent Kappa 500 ug 270.00
Description

PA007484.r2a: Recombinant Anti-mouse CD115 Monoclonal Antibody (Clone: AFS98), Rat IgG2a Kappa

Recombinant Rat IgG2a Monoclonal Antibody. 
Clone: AFS98.
Isotype:  Rat IgG2a Kappa.
Source: The anti-mouse CD115 monoclonal antibody (clone: AFS98) was produced in mammalian cells.
Conjugation: Non-conjugated.
Specificity/Sensitivity: The recombinant AFS98 antibody specifically binds to mouse CD115.
Applications: Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F). 
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Purity: >95% by SDS-PAGE under reducing conditions.

PA007484.h1Fs: Recombinant Anti-mouse CD115 Monoclonal Antibody (Clone: AFS98), Human IgG1 Fc Silent Kappa

Recombinant Human IgG1 Monoclonal Antibody with Fc silent mutation. 
Clone: AFS98.
Isotype: Human IgG1 kappa.
Source: The anti-mouse CD115 monoclonal antibody (clone: AFS98) was produced in mammalian cells.
Conjugation: Non-conjugated.
Specificity/Sensitivity: The recombinant AFS98 antibody specifically binds to mouse  CD115.
Applications: Flow cytometry (FC), and Immunohistochemistry - Frozen (IHC-F). 
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Purity: >95% by SDS-PAGE under reducing conditions.

PA007716.h1Fs-b: Biotinylated Recombinant Anti-mouse CD115 Monoclonal Antibody (Clone: AFS98), Human IgG1 Fc Silent Kappa

Recombinant human IgG1 monoclonal antibody with site-directed biotinylation through the Avi tag at the C-terminus of the antibody heavy chain.
Clone: AFS98.
Isotype:  Human IgG1 Fc Silent Kappa.
Source: The site-directed biotinylated anti-mouse CD115 monoclonal antibody (clone: AFS98) was produced in mammalian cells.
Conjugation: Biotin-conjugated.
Specificity/Sensitivity: The site-directed biotinylated recombinant AFS98 antibody specifically binds to mouse CD115.
Applications:  Flow cytometry (FC) with various dye conjugation through streptavidin; conjugation to streptavidin agarose beads or streptavidin magnetic beads.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Purity: >95% by SDS-PAGE under reducing conditions.

Shipping: The AFS98 antibody is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-Mouse CD115 Monoclonal Antibody (Clone: AFS98)

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice
Lim, A. K. H., et al. Diabetologia. 2009 Aug;52(8):1669-79. PMID: 19466391
Periglomerular and interstitial levels of ?-SMA were seen in accumulating myofibroblasts in a diabetic kidney from b a db/db mouse receiving control mAb; levels were reduced in c a diabetic db/db mouse treated with AFS98 mAb. ...Additional collagen IV deposition was found in the expanded mesangium and interstitial areas of a diabetic kidney from e a diabetic db/db mouse given control mAb; deposition was reduced in f a diabetic db/db mouse treated with AFS98 mAb. ...The elevated kidney levels of b phospho-ERK and c phospho-p38 in diabetic db/db mice given control mAb were not different from those of mice given AFS98 treatment. ...Our primary outcome was that AFS98 treatment reduced kidney macrophages in diabetic db/db mice. ...Another possibility is that the activation of glomerular macrophages is regulated indirectly by the effects of the diabetic milieu on mesangial cells or podocytes through cytokine secretion or cell-cell interactions and that these are unaffected by AFS98.
(Tags: activity of AFS98 antibody; function of AFS98 antibody)
Intraperitoneal administration of anti-c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E-deficient mice
Murayama, T., et al. Circulation. 1999 Apr 6;99(13):1740-6. PMID: 10190885
To elucidate the central role of macrophage and macrophage-colony stimulating factor (M-CSF) during atherogenesis, we used a new strategy to administer to adult apolipoprotein E (apoE)-deficient mice a monoclonal antibody (AFS98) raised against c-fms, the receptor of M-CSF. ...In contrast, when apoE-deficient mice that had been fed a high-fat diet from 6 weeks of age were given AFS98 from 12 to 18 weeks of age, a minimal protective effect on lesion size was observed. ...AFS98, a rat monoclonal anti-murine c-fms antibody (IgG2a), which inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor, has been described previously. ...Because AFS98 protected fatty streak formation, we next tested whether the antibody could have a similar preventive effect on the more advanced lesions. ...To confirm that the effect was specific for anti-c-fms antibody, we conducted additional experiments.
(Tags: AFS98 antibody for animal model; AFS98 antibody for cancer research)
Bone- and cartilage-protective effects of a monoclonal antibody against colony-stimulating factor 1 receptor in experimental arthritis
Bonnefoy, J. Y., et al. Arthritis Rheumatol. 2014 Nov;66(11):2989-3000. PMID: 24623505
We undertook this study to determine CSF-1R expression in human RA as well as the efficacy of a specific anti-CSF-1R monoclonal antibody (AFS98) in 2 different animal models of RA. ...The efficacy of AFS98 was examined by clinical assessment, histology, and bone histomorphometry in collagen-induced arthritis (CIA) and serum-transfer arthritis. ...CSF-1R expression was increased in the synovium of RA patients compared to OA patients and healthy controls in fibroblast-like synoviocytes, follicular dendritic cells, macrophages, and osteoclasts. ...In mice, blockade of CSF-1R abrogated cartilage damage, bone erosion, and systemic bone loss, and this was associated with the depletion of osteoclasts in both models. ...CSF-1R was broadly expressed in human RA. Blockade of CSF-1R protected against bone and cartilage destruction in both mouse models and also showed significant antiinflammatory effects in the CIA model.
(Tags: AFS98 antibody for flow cytometry; AFS98 antibody for mouse tumor model)
For more technical references or data sheets regarding the Recombinant Anti-Mouse CD115 Monoclonal Antibody (Clone: AFS98) formats, please contact our scientific support team at message@sydlabs.com or explore options via Syd Labs.

Syd Labs provides the following in vivo grade recombinant anti-mouse CD115 monoclonal antibodies:
Recombinant Anti-mouse CD115 monoclonal antibody (Clone: AFS98)

Related Links
Anti-mouse CD115 AFS98 Antibody for Flow Cytometry, Rat IgG2a Kappa
Anti-mouse CD115 Monoclonal Antibody (Clone: AFS98)
Anti-mouse CD115 AFS98 Antibody for Flow Cytometry, Human IgG1 kappa
Anti-mouse CD115 AFS98 Antibody, Rat IgG2a Kappa
Biotinylated Human M-CSF R/CSF1R/CD115 Protein
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