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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant mouse IgG1 Monoclonal Antibody.
Clone: HD109.
Isotype: Mouse IgG1 kappa.
Source: The anti-human CD205 (DEC-205) monoclonal antibody (clone: HD109) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: HD109) specifically binds to human CD205 (DEC-205).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD205 (DEC-205) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-human CD205 (DEC-205) monoclonal antibody of clone HD109 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-? signaling
Sato M, et al. Cancer Sci. 2020 Nov;111(11):4068-4080. doi: 10.1111/cas.14640. PMID: 33007133
The anti-CD109 antibody (HD109) was used for immunohistochemical staining of human lung adenocarcinoma, revealing CD109 protein expression correlating with tumor grade and prognosis. Representative histological images, alongside H&E staining, showed consistent CD109 positivity in serial sections of tumor samples.
Tags: anti-human CD205 (DEC-205) HD109; anti-human CD205 (DEC-205) HD109 antibody
HDAC10 deletion promotes Foxp3+ T-regulatory cell function
de Zoeten EF, et al. J Clin Invest. 2020 Feb 3;130(2):658-670. doi: 10.1172/JCI130339. PMID: 31949209
In studies combining T-effector (TE), CD90.2?, and regulatory T cells (TR) from WT or HDAC10?/? mice, HDAC10 deletion did not significantly alter baseline lymphocyte populations. Proliferation of co-stimulated TE cells was assessed via flow cytometry with CFSE dye dilution after three days, indicating enhanced Treg function in HDAC10?/? settings.
Tags: anti-human CD205 (DEC-205) HD109 antibody in vivo; anti-human CD205 (DEC-205) HD109 in animal model
HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma
Lee JH, et al. Cancer Res. 2020 Sep 1;80(17):3629-3641. doi: 10.1158/0008-5472.CAN-20-0600. PMID: 32540961
Hdac10 deletion accelerated KRAS-driven lung adenocarcinomas in mice, increasing macrophage infiltration and shortening survival. In vivo limiting dilution assays confirmed higher tumor incidence, suggesting HDAC10 as a potential tumor suppressor in KRAS-driven malignancies, with implications for CD109-targeted therapies.
Tags: anti-human CD205 (DEC-205) HD109 antibody in animal model; anti-human CD205 (DEC-205) HD109 in cancer research
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/?-catenin pathway
Li J, et al. Cell Death Dis. 2021 Jan 21;12(1):93. doi: 10.1038/s41419-021-03415-0. PMID: 33481334
HDAC10 overexpression reduced cervical cancer (CC) cell activities in vitro and tumor growth and lung metastases in vivo. Microarray and RT-qPCR showed low HDAC10 expression in CC cells, with miR-223 targeting TXNIP to promote CC development, suggesting a role for CD109-related pathways.
Tags: anti-human CD205 (DEC-205) HD109; function of anti-human CD205 (DEC-205) HD109
Histone deacetylase 10 promotes autophagy-mediated cell survival
Oehme I, et al. Autophagy. 2013 Sep;9(9):1497-509. doi: 10.4161/auto.25562. PMID: 23801752
HDAC10 knockdown disrupted autophagy in neuroblastoma cell lines, sensitizing them to cytotoxic drugs, unlike nontransformed cells. Western blot analysis of BE(2)-C cells showed altered LC3-I and LC3-II expression post-HDAC10 siRNA transfection, indicating HDAC10’s role in autophagy-mediated survival relevant to CD109-targeted therapies.
Tags: bioactivity of anti-human CD205 (DEC-205) HD109; anti-human CD205 (DEC-205) HD109 antibody of low endotoxin
For more references about anti-human CD205 (DEC-205) antibody (HD109), please contact our scientific support team with message@sydlabs.com.
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