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Recombinant mouse IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Mouse IgG1 Monoclonal Antibody.
Clone: 6A7M.
Isotype: Mouse IgG1 Kappa.
Source:The anti-human CD235a (Glycophorin A type M) monoclonal antibody (clone: 6A7M) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: 6A7M) specifically binds to human CD235a (Glycophorin A type M).
Applications:ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD235a (Glycophorin A type M) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The in vivo grade recombinant anti-human CD235a (Glycophorin A type M) monoclonal antibody of clone 6A7M is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
CD71+ Erythroid Cells Exacerbate HIV-1 Susceptibility, Mediate trans-Infection, and Harbor Infective Viral Particles.
Namdar, A., et al. mBio. 2019 Nov 26;10(6):e02767-19. doi: 10.1128/mBio.02767-19. PMID: 31772057
In contrast, we observed CECs bind to HIV-1 via CD235a and subsequently transfer the virus to uninfected CD4+ T cells, which can be partially blocked by the anti-CD235a antibody. ...They coexpress the transferrin receptor (CD71) and the erythroid lineage marker (TER119) in mice but CD71 and CD235a in humans. ...In contrast, HIV-1 binds to CD235a, and thus CECs cannot only trans-infect uninfected CD4+ T cells but also harbor infective virions in the presence of antiretroviral therapy (ART) drugs. ...Representative plots (B) and cumulative data (C) showing HIV trans-infection from RBCs of CD4+ T cells in the absence or presence of anti-CD235a antibody. ...More importantly, we observed more efficient interaction of HIV with CD235a on CECs compared to RBCs.
Tags: anti-human CD235a (Glycophorin A type M) 6A7M; anti-human CD235a (Glycophorin A type M) 6A7M mAb
For more references about Anti-human CD235a (Glycophorin A type M) Monoclonal Antibody please contact our scientific support team with message@sydlabs.com.
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