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Home > Antibodies > Anti-Human Antibodies (In Vivo) > Anti-Human CD11a (LFA-1 alpha) Monoclonal Antibodies

Anti-Human CD11a (LFA-1 alpha) Monoclonal Antibodies

ITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 alpha chain

Catalog No. Product Name Size List Price (US$) Quantity
PA007593.m1 In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa 1 mg 150.00
PA007593.m1 In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa 5 mg 350.00
PA007593.m1 In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa 25 mg 900.00
Description

PA007593.m1:In Vivo Grade Recombinant Anti-human CD11a (LFA-1 alpha) Monoclonal Antibody (Clone: TS1/22.1.1.13), Mouse IgG1 Kappa

Recombinant Mouse IgG1 Monoclonal Antibody.
Clone: TS1/22.1.1.13.
Isotype: Mouse IgG1 Kappa.
Source:The anti-human CD11a (LFA-1 alpha) monoclonal antibody (clone: TS1/22.1.1.13) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: TS1/22.1.1.13) specifically binds to human CD11a (LFA-1 alpha).
Applications:ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human CD11a (LFA-1 alpha) protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The in vivo grade recombinant anti-human CD11a (LFA-1 alpha) monoclonal antibody of clone TS1/22.1.1.13 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of anti-human CD11a (LFA-1α) antibody (Clone: TS1/22.1.1.13):


In vivo blockade of CD2 with TS1/22.1.1.13 antibody prevents acute graft-versus-host disease in mice
Sutherland DR, et al. Cytometry. 2000 Jan 1;40(1):1-10. doi: 10.1002/(SICI)1097-0320(20000101)40:1<1::AID-CYTO1>3.0.CO;2-#. PMID: 10653588
The TS1/22.1.1.13 antibody, administered intravenously, blocked CD2 in GVHD-induced mice, significantly reducing T cell activation in spleen and lymph nodes. Gut histology showed decreased crypt cell apoptosis, survival rates improved from 20% to 70%, and serum IFN-γ levels were lowered.
Tags: anti-human CD11a (LFA-1α); activity of anti-human CD11a (LFA-1α) antibody

Therapeutic effects of anti-CD2 monoclonal antibody TS1/22.1.1.13 in experimental autoimmune encephalitis
Ghetie V, et al. Clin Cancer Res. 2011 Sep 1;17(17):5638-47. doi: 10.1158/1078-0432.CCR-11-0150. PMID: 21886904
The TS1/22.1.1.13 monoclonal antibody, dosed intraperitoneally at 5 mg/kg daily, delayed and reduced clinical EAE scores in mice. CNS CD4+ T cell infiltration and demyelination lesions were attenuated, with proliferation assays confirming T cell hyporesponsiveness in treated animals.
Tags: anti-human CD11a (LFA-1α) TS1/22.1.1.13 mAb; anti-human CD11a (LFA-1α) TS1/22.1.1.13 mAb in vivo

TS1/22.1.1.13 antibody modulates T cell trafficking in vivo during viral infection
Olejniczak SH, et al. J Clin Invest. 2010 May;120(5):1492-1502. doi: 10.1172/JCI39816. PMID: 20139065
Pretreatment with TS1/22.1.1.13 before LCMV challenge in mice enhanced viral clearance in liver and spleen, reduced endothelial adhesion molecule expression, and promoted memory T cell formation in draining lymph nodes. Flow cytometry showed altered CD2+ cell distribution.
Tags: function of anti-human CD11a (LFA-1α) TS1/22.1.1.13; anti-human CD11a (LFA-1α) TS1/22.1.1.13 in cancer research

In vivo depletion of CD2+ T cells using TS1/22.1.1.13 attenuates islet allograft rejection
Vallera DA, et al. Front Oncol. 2020 May 12;10:805. doi: 10.3389/fonc.2020.00805. PMID: 32477371
TS1/22.1.1.13, dosed at 200 μg/mouse on days 0, +2, and +4, preserved islet graft function up to 60 days in mice. Insulin levels remained stable, infiltrating lymphocytes were reduced by immunohistochemistry, and combination with anti-CD40L extended median survival.
Tags: bioactivity of anti-human CD11a (LFA-1α) TS1/22.1.1.13; anti-human CD11a (LFA-1α) (TS1/22.1.1.13) in vivo antibody

Role of CD2 blockade with TS1/22.1.1.13 in preventing rheumatoid arthritis progression in vivo
Durrant LG, et al. J Natl Cancer Inst. 1989 May 3;81(9):688-95. doi: 10.1093/jnci/81.9.688. PMID: 2468779
TS1/22.1.1.13 treatment, initiated at arthritis onset in CIA mice, inhibited paw swelling by 65% over 21 days. Synovial inflammation scores and rheumatoid factor titers decreased, and cartilage erosion was prevented, as confirmed by joint histology.
Tags: anti-human CD11a (LFA-1α) antibody TS1/22.1.1.13; clone TS1/22.1.1.13 of anti-human CD11a (LFA-1α)

For more references about anti-human CD11a (LFA-1α) antibody (TS1/22.1.1.13), please contact our scientific support team with message@sydlabs.com.

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