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VEGF-B Protein

Vascular Endothelial Growth Factor B
Catalog No. Product Name Size List Price (US$) Quantity
BP000261-CYT-628 Recombinant Human VEGF-B 10 ug 160.00
BP000261-CYT-628 Recombinant Human VEGF-B 1 mg 5200.00
Description

Introduction
VEGFB is a growth factor for endothelial cells. VEGFB 167 a.a. binds heparin and neuropilin-1 while the binding to neuropilin-1 of VEGFB 186 a.a. is regulated by proteolysis. Overexpression of VEGFB in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Increased VEGFB expression is associated with hepatocellular carcinoma. VEGF-B has restricted angiogenic activity in the ischemic heart. VEGFB binds to VEGFR1, Flt1, but not to VEGFR2 and VEGFR3. VEGFB is homodimeric, heparin-binding glycoprotein involved in embryonic angiogenesis and vasculogenesis.

BP000261-CYT-628: Recombinant Human VEGF-B (Vascular Endothelial Growth Factor B)

Source: E. coli-derived.
A double, non-glycosylated, polypeptide chain containing 207 amino acids (22-207) and having a molecular mass of 21.6 kDa.
Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast. The ED50 for this effect is < 1 ug/ml corresponding to a specific activity of less than 1,000,000 units/mg.
Purity > 90%, by SDS-PAGE.
Formulation: The VEGFB protein solution contains 20 mM Tris-HCl buffer pH 7.5 & 10% glycerol.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

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