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Conditions of optimal VEGI protein performance should be determined experimentally by the investigator.
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Introduction
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
BP000262-CYT-517: Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) Protein
Source: E. coli-derived.
A double, non-glycosylated, polypeptide chain containing 192 amino acids and having a molecular mass of 21.8 kDa.
The ED50 as determined by the dose-dependant inhibition of the proliferation of HUVEC (Human Umbilical Vein Endothelial Cells) is less then 5000 ug/ml corresponding to a Specific Activity of 200 IU/mg.
Purity: > 95% by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from a concentrated (1 ug/ml) solution containing 0.5 M NaCl and 50 mM Tris-HCl pH-7.5.
Reconstitution: It is recommended to reconstitute the lyophilized TNFSF15 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other TNFSF15 Proteins:
Recombinant Human TNFSF15 Protein, His Tag
Recombinant Human TNFSF15 Protein
TNFSF15 Antibody:
TNFSF15 Polyclonal Antibody
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