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Conditions of optimal VEGI protein performance should be determined experimentally by the investigator.
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Introduction
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
BP000262-C038: Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) Protein
Source: E. coli-derived.
Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) Protein is a single non-glycosylated polypeptide chain containing 192 amino acids with a molecular mass of 21,858 Daltons.
N-terminal sequence analysis: Met-Gln-Leu-Thr-Lys.
Predicted molecular mass: 21,858 Daltons.
The specific activity of Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) Protein is calculated by its ability to the dose-dependent inhibition of the proliferation of HUVEC cells. The ED50 for this effect is typically < 5 ug/ml.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 EU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 250 mM NaCl, pH 7.5.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other TNFSF15 Proteins:
Recombinant Human TNFSF15 Protein
Recombinant Human TNFSF15 Protein, His Tag
TNFSF15 Antibodies:
TNFSF15 Polyclonal Antibody
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