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Introduction
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a TNF homology domain (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
BP000129-CYT-546: Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 10 (TNFSF10) Protein (114-281 a.a.)
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 169 amino acids (114-281) and having a molecular mass of 19.6 kDa.
Purity: > 95% by SDS-PAGE
Formulation: TRAIL in 20 mM Tris pH-7.5, 300 mM NaCl, 0.1 mM DTT & 10% glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other TNFSF10 Proteins:
Recombinant Human TNFSF10 Protein
Recombinant Human TNFSF10 Protein
Recombinant Human TNFSF10 Protein
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