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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal STUB1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
E3 ubiquitin-protein ligase CHIP, also known as homology and U box-containing protein 1, Carboxy terminus of Hsp70-interacting protein, CLL-associated antigen KW-8, Antigen NY-CO-7, CHIP, STUB1, is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
BP001120-HSP-019: Recombinant Human E3 Ubiquitin-Protein Ligase CHIP (CHIP)
Source: E. coli-derived.
Recombinant Human E3 Ubiquitin-Protein Ligase CHIP (CHIP) is a single, non-glycosylated polypeptide chain containing 303 amino acids and having a molecular mass of 34.8 kDa. STUB1 is expressed and purified by proprietary chromatographic techniques.
Purity: > 90.0% by SDS-PAGE.
Formulation: The STUB1 protein solution contains 20 mM Tris-HCl, pH-7.5, 10% glycerol and 5 mM DTT.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other STUB1 Proteins:
Recombinant Human CHIP Protein
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