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Conditions of optimal RARA Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Retinoic acid receptor alpha (RAR) belongs to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. There are three isotypes of RAR proteins: alpha, beta, and gamma. The RAR proteins are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically, RAR-alpha represses target gene transcription in the absence of hormone, whereas RAR-beta and gamma fail to repress under these conditions. RARA is a receptor for retinoic acid that has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. RARA controls cell function by directly regulating gene expression. Chromosomal aberrations involving RARA cause acute promyelocytic leukemia (APL).
BP003002-PRO-596: Recombinant human Retinoic Acid Receptor Alpha (RARA) Protein
Source: E. coli-derived.
Recombinant human Retinoic Acid Receptor Alpha (RARA) Protein fused to N-terminal His-Tag is a single, non-glycosylated polypeptide chain containing 127 amino acids and having a molecular mass of 14 kDa.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The protein solution contains 20 mM Tris pH-7.5, 0.1 M NaCl & 5 mM b-ME.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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