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PCNA Protein

Proliferating Cell Nuclear Antigen, Cyclin, MGC8367

Catalog No. Product Name Size List Price (US$) Quantity
BP002389-PRO-615 Recombinant Human Proliferating Cell Nuclear Antigen Protein 25 ug 160.00
BP002389-PRO-615 Recombinant Human Proliferating Cell Nuclear Antigen Protein 1 mg 2700.00
Description

Introduction
PCNA is located in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps elevate the processivity of leading strand synthesis during DNA replication. In reaction to DNA damage, PCNA is ubiquitinated and takes part in the RAD6-dependent DNA repair pathway. 2 transcript variants encoding the same protein have been found for PCNA gene. Pseudogenes of this PCNA gene have been described on chromosome 4 and on the X chromosome. PCNA is expressed during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA is induced by UV irradiation.

BP002389-PRO-615: Recombinant Human Proliferating Cell Nuclear Antigen (PCNA) Protein

Source: E. coli-derived.
Recombinant Human PCNA protein is a single, non-glycosylated polypeptide chain containing 261 amino acids and having a molecular mass of 28769 Dalton.
Purity: > 95.0% as determined by RP-HPLC and SDS-PAGE.
Formulation: The PCNA solution contains 20 mM Tris pH-7.5 & 2 mM EDTA & 20% glycerol.

Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.

Other PCNA Proteins:
Recombinant Human Proliferating Cell Nuclear Antigen, Sf9 Protein
Recombinant Human Proliferating Cell Nuclear Antigen, GST Tag Protein

PCNA Antibodies:
PCNA Monoclonal Antibody

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