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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal PAI-1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Plasminogen activator inhibitor 1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis1-2. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue3. It is normally present at low levels in plasma and tissue, but its expression and release increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome4. PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases5-8. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.
BP000018-ENZ-356: Human Plasminogen activator inhibitor 1 (PAI-1) Protein
Human Plasminogen activator inhibitor 1 (PAI-1) Protein, stable mutant 14-1B has a Molecular mass of 43 kDa. This human form of SERPINE1 contains the following four mutations: K154T, Q139L, M354I and N150H. These mutations combine to confer great stability to the otherwise labile molecule essentially locking it into the active conformation. Human Plasminogen activator inhibitor-1 (PAI-1) Protein is purified by proprietary chromatographic techniques.
Purity: > 95.0% by RP-HPLC and SDS-PAGE.
Formulation: 0.05 M sodium phosphate 0.1 M NaCl and 1 mM EDTA (pH 6.6).
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other PAI-1 Proteins:
Recombinant Human PAI-1 Protein
Recombinant Human PAI-1 Protein
PAI-1 ELISA Kit:
Human PAI-1 ELISA Kit
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