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Conditions of optimal PAI-1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Plasminogen activator inhibitor 1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis1-2. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue3. It is normally present at low levels in plasma and tissue, but its expression and release increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome4. PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases5-8. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.
BP000018-C537: Recombinant Human Plasminogen activator inhibitor 1 (PAI-1) Protein
Source: HEK 293-derived.
Recombinant Human Plasminogen activator inhibitor 1 (PAI-1) Protein is a secreted protein with sequence (Val24-Pro402) of Human SERPINE1 fused with a poly-histidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.0.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other PAI-1 Proteins:
Recombinant Human PAI-1 Protein
Human PAI-1 Protein
PAI-1 ELISA Kits:
Human PAI-1 ELISA Kit
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