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Omalizumab Biosimilar, IgE Monoclonal Antibody

Research Grade Xolair Biosimilar, Anti-IgE Humanized Monoclonal Antibody

Catalog No. Product Name Size List Price (US$) Quantity
C020P Omalizumab Biosimilar, Human IgE Monoclonal Antibody 10 mg 800.00
C020P Omalizumab Biosimilar, Human IgE Monoclonal Antibody 50 mg 1200.00
C020P Omalizumab Biosimilar, Human IgE Monoclonal Antibody 100 mg 2000.00
C020P Omalizumab Biosimilar, Human IgE Monoclonal Antibody 1 g 6000.00
Description

Omalizumab (trade name Xolair, Roche/Genentech and Novartis) is a humanized antibody used to reduce sensitivity to inhaled or ingested allergens, especially in the control of moderate to severe allergic asthma which does not respond to high doses of corticosteroids.

Immunoglobulin E (IgE) found in mammals only exists as monomers consisting of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). In addition to immunity to parasites, IgE plays an essential role in type I hypersensitivity, which manifests various allergic diseases, and allergic conditions, such as anaphylactic reactions to certain drugs, bee stings, and antigen preparations used in specific desensitization immunotherapy.

C020P: Omalizumab Biosimilar, Human IgE Monoclonal Antibody

Recombinant Humanized IgG1 Monoclonal Antibody.
Isotype: Human IgG1.
Source: The monoclonal antibody Omalizumab was produced in the Xolair biosimilar CHO stable cell line.
Specificity/Sensitivity: The monoclonal antibody Omalizumab specifically binds to the human immunoglobulin E (IgE) free in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells.
Applications: Functional assay, neutralization, blocking, ELISA.
Form of Antibody: 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives.
Endotoxin: < 0.1 EU per 1 ug of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The monoclonal antibody Omalizumab is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

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