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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal IL-15 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Human interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL15 binds to the alpha subunit of the IL15 receptor (IL15RA) with high affinity. IL15 also binds to the beta and gamma chains of the IL2 receptor, but not the alpha subunit of the IL2 receptor. IL15 is structurely and functionally related to IL2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. CD8+ memory T cell number is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature human IL15 shares 70% amino acid sequence identity with mouse and rat IL15.
BP000137-CYT-490: Recombinant Human Interleukin-15 (IL-15) Protein, His Tag
Source: E. coli-derived.
A single, non-glycosylated, Polypeptide chain containing 123 amino acids fragment (49-162) having a total molecular weight of 13.9 kDa with an C-terminal hexahistidine tag.
Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 2.5 ng/ml concentration corresponding to a Specific Activity of 0.4 MIU/mg.
Purity: > 95% by SDS-PAGE.
Formulation: IL-15 His is supplied in 20 mM Tris-HCl buffer (pH 8.0) 0.2 um PMSF and 10% glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other IL-15 Proteins:
Recombinant Rat IL-15 Protein
Recombinant Porcine IL-15 Protein
Recombinant Mouse IL-15 Protein
Recombinant Human IL-15 Protein
Recombinant Human IL-15 Protein
Recombinant Mouse IL-15 Protein, His Tag
IL-15 Antibodies:
IL-15 Monoclonal Antibody
IL-15 ELISA Kits:
Human IL-15 ELISA Kit
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