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Conditions of optimal IL-15 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Human interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL15 binds to the alpha subunit of the IL15 receptor (IL15RA) with high affinity. IL15 also binds to the beta and gamma chains of the IL2 receptor, but not the alpha subunit of the IL2 receptor. IL15 is structurely and functionally related to IL2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. CD8+ memory T cell number is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature human IL15 shares 70% amino acid sequence identity with mouse and rat IL15.
BP000137-CYT-403: Recombinant Porcine Interleukin-15 (IL-15) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 114 amino acids and having a molecular mass of 13,118 Dalton.
The ED50 as determined by the dose-dependant stimulation of the proliferation of mouse CTLL-2 was found to be < 0.2 ng/ml corresponding to a Specific Activity of 5 MIU/mg.
Purity: > 95% by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from a concentrated (1 ug/ml) solution containing no additives.
Reconstitution: It is recommended to reconstitute the lyophilized Interleukin-15 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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